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1. (WO1998049269) GENETICALLY ENGINEERED ANIMALS CONTAINING NULL MUTATIONS IN THE NEUROFILAMENT GENES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/049269 International Application No.: PCT/US1998/008877
Publication Date: 05.11.1998 International Filing Date: 01.05.1998
IPC:
A61K 49/00 (2006.01) ,C07K 14/47 (2006.01) ,C12N 15/85 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
Applicants:
MOUNT SINAI SCHOOL OF MEDICINE OF THE CITY UNIVERSITY OF NEW YORK [US/US]; One Gustave L. Levy Place New York, NY 10029-6574, US (AllExceptUS)
LAZZARINI, Robert, A. [US/US]; US (UsOnly)
ELDER, Gregory [US/US]; US (UsOnly)
Inventors:
LAZZARINI, Robert, A.; US
ELDER, Gregory; US
Agent:
CLARK, Richard, S. ; Baker & Botts, LLP 30 Rockefeller Plaza New York, NY 10112-0228, US
Priority Data:
60/045,26401.05.1997US
Title (EN) GENETICALLY ENGINEERED ANIMALS CONTAINING NULL MUTATIONS IN THE NEUROFILAMENT GENES
(FR) ANIMAUX OBTENUS PAR GENIE GENETIQUE COMPORTANT DES GENES DE NEUROFILAMENTS EXEMPTS DE MUTATIONS
Abstract:
(EN) The present invention provides for genetically engineered non-human animals, including but not limited to mice, which lack one or more endogenous neurofilament gene. Human neurofilament genes may be introduced into such genetically non-human animals (referred to hereafter as 'knockout animals') to produce improved models of the physiology of human neurofilament proteins which may be used to study human neurofilament-associated neurodegenerative conditions.
(FR) L'invention porte sur des animaux non humains obtenus par génie génétique dont non exclusivement des souris à qui manque un ou plusieurs des gènes endogènes de neurofilaments. Des gènes humains de neurofilaments peuvent être introduits dans les susdits animaux (appelés ci-après 'knock out animals') pour produire des modèles améliorés de la physiologie des protéines de neurofilaments humains pouvant servir à l'étude d'états neurodégénératifs associés aux neurofilaments humains.
Designated States: AU, CA, JP, US
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1998074705