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1. (WO1998049202) NOVEL HETERO-POLYSACCHARIDE CONJUGATES, NOVEL s-INP POLYSACCHARIDE GELS AND METHODS OF MAKING AND USING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/049202 International Application No.: PCT/US1998/008752
Publication Date: 05.11.1998 International Filing Date: 30.04.1998
Chapter 2 Demand Filed: 13.11.1998
IPC:
A61K 9/16 (2006.01) ,A61K 9/50 (2006.01) ,A61K 9/70 (2006.01) ,A61L 17/14 (2006.01) ,A61L 27/38 (2006.01) ,C08L 5/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
16
Agglomerates; Granulates; Microbeadlets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
70
Web, sheet or filament bases
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
17
Materials for surgical sutures or for ligaturing blood vessels
14
Post-treatment to improve physical properties
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
36
containing ingredients of undetermined constitution or reaction products thereof
38
Animal cells
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
L
COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
5
Compositions of polysaccharides or of their derivatives not provided for in group C08L1/ or C08L3/142
04
Alginic acid; Derivatives thereof
Applicants:
BIOMM, INCORPORATED [US/US]; 14775 S.W. 132 Place Miami, FL 33186, US
Inventors:
MARES-GUIA, Marcos; US
RICORDI, Camillo; US
Agent:
HAUG, Edgar, H. ; Frommer Lawrence & Haug LLP 745 Fifth Avenue New York, NY 10151, US
Priority Data:
08/877,68217.06.1997US
60/045,11130.04.1997US
Title (EN) NOVEL HETERO-POLYSACCHARIDE CONJUGATES, NOVEL s-INP POLYSACCHARIDE GELS AND METHODS OF MAKING AND USING THE SAME
(FR) NOUVEAUX CONJUGUES D'HETERO-POLYSACCHARIDES, NOUVEAUX GELS DE POLYSACCHARIDE A RESEAUX POLYMERES A SEMI-INTERPENETRATION ET PROCEDES DE PRODUCTION ET D'UTILISATION DESDITS GELS
Abstract:
(EN) Disclosed and claimed are: a composition including at least one glycosaminoglycan, e.g., CIS, and at least one alginate, e.g., sodium alginate, wherein: the at least one glycosaminoglycan and/or the algninate are cross-linked or polymerized, e.g., the alginate is cross-linked or polymerized, for instance by addition of an inorganic salt, such as a calcium salt; or the at least one glycosaminoglycan and the alginate are covalently bound, e.g., by means of a coupling reaction involving a linker molecule such as DVS; or the at least one glycosaminoglycan and/or the alginate are cross-linked or polymerized, e.g., the alginate is cross-linked or polymerized, for instance by addtion of an inorganic salt, such as a calcium salt, and the at least one glycosaminoglycan and the alginate are covalently bound, e.g., by means of a coupling reaction involving a linker molecule such as DVS, and the covalent binding can have been performed prior to cross-linking or polymerizing or $i(vice versa); and, gels comprising the composition; mixtures of such gels or of at least one such gel and at least one such composition; and, methods for making and using such compositions and gels, including products therefrom such as 'paints', sprays, matrices, beads, microcapsules.
(FR) Composition comportant au moins un glycosaminoglycane, par ex. CIS, et au moins un alginate, par ex. de l'alginate de sodium. Selon la présente invention, le glycosaminoglycane et/ou l'alginate sont réticulés et polymérisés, par ex. l'alginate est réticulé ou polymérisé, par exemple par ajout d'un sel inorganique, tel que du sel de calcium. Alternativement, le glycosaminoglycane et l'alginate sont liés par liaison covalente, par ex. à l'aide d'une réaction de liaison impliquant une molécule de liaison telle que DVS. Alternativement, le glycosaminoglycane et/ou l'alginate sont réticulés ou polymérisés, par ex. l'alginate est réticulé ou polymérisé, par exemple par ajout d'un sel inorganique, tel qu'un sel de calcium, et le glycosaminoglycane et l'alginate sont liés de manière covalente, par ex. au moyen d'une réaction de liaison impliquant une molécule de liaison telle que DVS, et la liaison covalente peut avoir été effectuée avant la réticulation ou la polymérisation ou vice versa. La présente invention concerne également des gels contenant ladite composition, des mélanges de ces gels ou d'au moins un gel de ce type et d'au moins une telle composition, ainsi que des procédés de préparation et d'utilisation de ces compositions et gels, et des produits qui en résultent tels que des 'peintures', des sprays, des matrices, des perles et des microcapsules.
Designated States: BR
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)