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1. (WO1998049198) SINGLE-CHAIN ANTIGEN-BINDING PROTEINS CAPABLE OF GLYCOSYLATION, PRODUCTION AND USES THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/049198 International Application No.: PCT/US1998/008662
Publication Date: 05.11.1998 International Filing Date: 30.04.1998
Chapter 2 Demand Filed: 30.11.1998
IPC:
A61K 47/48 (2006.01) ,C07K 16/00 (2006.01) ,C07K 16/30 (2006.01) ,G01N 33/68 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
30
from tumour cells
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
ENZON, INC. [US/US]; 20 Kingsbridge Road Piscataway, NJ 08854-3963, US
Inventors:
FILPULA, David R.; US
WANG, Maoliang; US
SHORR, Robert G.L.; US
WHITLOW, Marc D.; US
LEE, Lihsyng, S.; US
Agent:
GOLDSTEIN, Jorge, A. ; Sterne, Kessler, Goldstein & Fox P.L.L.C. Suite 600 1100 New York Avenue, N.W. Washington, DC 20005-3934, US
Priority Data:
60/044,44930.04.1997US
60/050,47223.06.1997US
60/063,07427.10.1997US
60/067,34102.12.1997US
Title (EN) SINGLE-CHAIN ANTIGEN-BINDING PROTEINS CAPABLE OF GLYCOSYLATION, PRODUCTION AND USES THEREOF
(FR) PROTEINES A CHAINE UNIQUE FIXANT LES ANTIGENES CAPABLES DE GLYCOSYLATION, PRODUCTION ET UTILISATIONS DE CES DERNIERES
Abstract:
(EN) The present invention relates to single-chain antigen-binding molecules capable of glycosylation. Compositions of, genetic constructions coding for, and methods for producing monovalent and multivalent single-chain antigen-binding molecules capable of glycosylation are described and claimed. Compositions of, genetic constructions coding for, and methods for producing glycosylated monovalent and multivalent single-chain antigen-binding molecules capable of polyalkylene oxide conjugation are described and claimed. The invention also relates to methods for producing a polypeptide having increased glycosylation and the polypeptide produced by the described method. Uses resulting from the multifunctionality of a glycosylated/polyalkylene oxide conjugated antigen-binding protein are also described and claimed.
(FR) La présente invention concerne des molécules à chaîne unique fixant les antigènes capables de glycosylation. L'invention se rapporte à des compositions de ces molécules à chaîne unique monovalentes ou multivalentes fixant les antigènes capables de glycosylation, à des constructions génétiques codant ces dernières et à des procédés de production de celles-ci. L'invention se rapporte également à une composition de molécules à chaîne unique monovalentes ou multivalentes glycosylées fixant les antigènes capables de se conjuguer à un oxyde de polyalkylène, à des constructions génétiques codant ces dernières et à des procédés de production de celles-ci. L'invention concerne aussi des procédés de production d'un polypeptide présentant une glycosylation accrue et le polypeptide produit selon le procédé décrit. L'invention se rapporte enfin à des utilisations de la multifonctionnalité de la protéine fixant les antigènes glycosylée/conjuguée à l'oxyde de polyalkylène.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0981548JP2002516610 CA2288992AU1998072668