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1. (WO1998049184) ISOLATED NUCLEIC ACID MOLECULE CODING FOR TUMOR REJECTION ANTIGEN PRECURSORS MAGE-C1 AND MAGE-C2 AND USES THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/049184 International Application No.: PCT/US1998/008493
Publication Date: 05.11.1998 International Filing Date: 24.04.1998
Chapter 2 Demand Filed: 20.11.1998
IPC:
C07K 14/47 (2006.01) ,G01N 33/569 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
569
for micro-organisms, e.g. protozoa, bacteria, viruses
Applicants:
LUDWIG INSTITUTE FOR CANCER RESEARCH [CH/US]; 605 Third Avenue New York, NY 10158, US
Inventors:
LUCAS, Sophie; BE
DE SMET, Charles; BE
BOON-FALLEUR, Thierry; BE
Agent:
SCHOFIELD, Mary, Anne; Fulbright & Jaworski L.L.P. 666 Fifth Avenue New York, NY 10105, US
Priority Data:
08/845,52825.04.1997US
Title (EN) ISOLATED NUCLEIC ACID MOLECULE CODING FOR TUMOR REJECTION ANTIGEN PRECURSORS MAGE-C1 AND MAGE-C2 AND USES THEREOF
(FR) MOLECULE D'ACIDE NUCLEIQUE ISOLEE CODANTE POUR LE PRECURSEUR D'ANTIGENE DE REJET TUMORAL MAGE-C1 ET MAGE-C2 ET SES UTILISATIONS
Abstract:
(EN) The invention relates to isolated nucleic acid molecules which code for antigens expressed by tumor cells which may be recognized by cytotoxic T cells, leading to lysis of the tumor cells which express it. This invention also relates to vectors which are designed to encode the antigen expressed by tumor cells and also to cells transfected by the nucleic acid molecules or vectors which comprise the nucleic acid molecules. Various therapeutic and diagnostic uses arising out of the properties of the nucleic acid molecules and the antigens for which these code are also part of this invention.
(FR) L'invention concerne des molécules d'acide nucléique isolées codantes pour des antigènes exprimés par des cellules tumorales pouvant être reconnues par des cellules T cytotoxiques, ce qui conduit à la lyse des cellules tumorales qui l'expriment. Cette invention concerne également des vecteurs conçus pour coder l'antigène exprimé par des cellules tumorales, ainsi que des cellules transfectées par les molécules d'acide nucléique ou par les vecteurs comprenant les molécules d'acide nucléique. Cette invention a enfin pour objet diverses utilisations diagnostiques et thérapeutiques tirées des propriétés que présentent les molécules d'acide nucléique et les antigènes qu'elles codent.
Designated States: AU, CA, CN, JP, KR, NZ
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0979235JP2002503096 DK0979235AU1998071665