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1. (WO1998049170) SPIRO-AZACYCLIC DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS

Pub. No.:    WO/1998/049170    International Application No.:    PCT/GB1998/001179
Publication Date: Fri Nov 06 00:59:59 CET 1998 International Filing Date: Thu Apr 23 01:59:59 CEST 1998
IPC: C07D 491/10
Applicants: MERCK SHARP & DOHME LIMITED
CURTIS, Neil, Roy
ELLIOTT, Jason, Matthew
HOLLINGWORTH, Gregory, John
JACKSON, Philips, Stephen
KULAGOWSKI, Janusz, Jozef
SEWARD, Eileen, Mary
SWAIN, Christopher, John
WILLIAMS, Brian, John
Inventors: CURTIS, Neil, Roy
ELLIOTT, Jason, Matthew
HOLLINGWORTH, Gregory, John
JACKSON, Philips, Stephen
KULAGOWSKI, Janusz, Jozef
SEWARD, Eileen, Mary
SWAIN, Christopher, John
WILLIAMS, Brian, John
Title: SPIRO-AZACYCLIC DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS
Abstract:
Substituted spiro-azacyclic derivatives of structural formula (I) are tachykinin receptor antagonists of use, for example, in the treatment or prevention of pain, inflammation, migraine, emesis and postherpetic neuralgia.