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1. (WO1998049168) REVERSE-TURN MIMETICS AND METHODS RELATING THERETO
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/049168 International Application No.: PCT/US1998/008542
Publication Date: 05.11.1998 International Filing Date: 28.04.1998
Chapter 2 Demand Filed: 18.11.1998
IPC:
A61K 38/00 (2006.01) ,C07D 487/04 (2006.01) ,C07D 498/04 (2006.01) ,C07K 5/078 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
498
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
06
Dipeptides
078
the first amino acid being heterocyclic, e.g. Pro, His, Trp
Applicants:
MOLECUMETICS LTD. [US/US]; Suite 400 2023 - 120th Avenue N.E. Bellevue, WA 98005, US
Inventors:
KAHN, Michael, S.; US
EGUCHI, Masakatsu; US
KIM, Hwa-Ok; US
Agent:
HERMANNS, Karl, R. ; Seed and Berry LLP 6300 Columbia Center 701 Fifth Avenue Seattle, WA 98104-7092, US
GOWSHALL, Jonathan, Vallance; Forrester & Boehmert Franz-Joseph-Strasse 38 D-80801 München, DE
Priority Data:
08/846,43230.04.1997US
Title (EN) REVERSE-TURN MIMETICS AND METHODS RELATING THERETO
(FR) MIMETIQUES A ROTATION INVERSE ET PROCEDES ASSOCIES
Abstract:
(EN) Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetics have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetics of this invention are also disclosed, as well as methods for screening the same to identify biologically active members.
(FR) On décrit des composés à conformation contrainte qui imitent la structure secondaire de régions à rotation inverse de protéines et de peptides biologiquement actifs. Ces mimétiques à rotation inverse sont utiles dans de nombreux domaines, y compris en tant qu'agents de diagnostic et de thérapie. On décrit également des bibliothèques contenant les mimétiques à rotation inverse de cette invention, ainsi que des procédés de criblage de ces derniers utiles pour identifier des éléments biologiquement actifs.
Designated States: AU, CA, JP, KR
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)