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1. (WO1998049165) CYTOTOXIC COMPOUNDS: DERIVATIVES OF THE PYRIDO[2,3,4-$i(kl)] ACRIDINE RING SYSTEM
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/049165 International Application No.: PCT/GB1998/001239
Publication Date: 05.11.1998 International Filing Date: 29.04.1998
Chapter 2 Demand Filed: 17.11.1998
IPC:
C07D 471/06 (2006.01) ,C07D 471/16 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
06
Peri-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
12
in which the condensed system contains three hetero rings
16
Peri-condensed systems
Applicants:
UNIVERSIDAD COMPLUTENSE DE MADRID [ES/ES]; Ciudad Universitaria Rectorado E-28040 Madrid, ES (AT, AU, BE, BR, CA, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, JP, KR, LU, MC, MX, NL, NZ, PT, RU, SE, UA)
RUFFLES, Graham, Keith [GB/GB]; GB (AL, AM, AT, AZ, BA, BB, BE, BF, BG, BJ, BY, CF, CG, CH, CI, CM, CN, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, GW, HU, ID, IE, IL, IS, IT, KE, KG, KP, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, NE, NL, NO, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UG, UZ, VN, YU, ZW)
FERNANDEZ PUENTES, José Luis [ES/ES]; ES (UsOnly)
GARCIA GRAVALOS, Dolores [ES/ES]; ES (UsOnly)
AVENDAÑO LOPEZ, Carmen [ES/ES]; ES (UsOnly)
BLANCO CASTRO, Maria del Mar [ES/ES]; ES (UsOnly)
MENENDEZ RAMOS, José Carlos [ES/ES]; ES (UsOnly)
Inventors:
FERNANDEZ PUENTES, José Luis; ES
GARCIA GRAVALOS, Dolores; ES
AVENDAÑO LOPEZ, Carmen; ES
BLANCO CASTRO, Maria del Mar; ES
MENENDEZ RAMOS, José Carlos; ES
Agent:
RUFFLES, Graham, Keith; Marks & Clerk 57-60 Lincoln's Inn Fields London WC2A 3LS, GB
Priority Data:
9708751.429.04.1997GB
Title (EN) CYTOTOXIC COMPOUNDS: DERIVATIVES OF THE PYRIDO[2,3,4-$i(kl)] ACRIDINE RING SYSTEM
(FR) COMPOSES CYTOTOXIQUES: DERIVES DU SYSTEME CYCLIQUE PYRIDO[2,3,4-$i(kl)] ACRIDINE
Abstract:
(EN) Compounds of formula (I), wherein X is selected from the group consisting of O, and NR3, where R3 represents a lower alkyl group; Y is selected from the group consisting of CH and N; R1 and R2 are independently selected from the group consisting of NH2, NHR4 and NR52, where R4 and R5 each represent a lower alkyl group, or R1 and R2 together represent a cycle selected from (a), (b) and (c), wherein R6, R7 and R8 are independently selected from the group consisting of hydrogen atoms, lower alkyl groups, hydroxy groups and lower alkoxy groups; and Z is selected from the group consisting of O.
(FR) L'invention concerne des composés de formule (I) (I) dans laquelle: X est choisi dans le groupe composé de O et NR3, R3 représentant un groupe alkyle inférieur; Y est choisi dans le groupe composé de CH et N; R1 et R2 sont choisis indépendamment dans le groupe composé de NH2, NHR4, et NR52, R4 et R5 représentant chacun un groupe alkyle inférieur, ou R1 et R2 représentant ensemble un cycle choisi parmi a), b), et c): dans lesquels R6, R7, et R8 sont choisis indépendamment dans le groupe composé des atomes d'hydrogène, des groupes alkyles inférieurs, des groupes hydroxy, et des groupes alkoxy inférieurs; et Z est choisi dans le groupe composé de O.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0980372US20020128281JP2001522370 CA2287862AU1998072208