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1. (WO1998049127) PROCESS FOR PRODUCING KETOPROFEN AND 5-BENZOYL-3-METHYL-2-INDOLINONE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/049127 International Application No.: PCT/JP1998/001939
Publication Date: 05.11.1998 International Filing Date: 28.04.1998
Chapter 2 Demand Filed: 18.11.1998
IPC:
C07D 209/34 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
04
Indoles; Hydrogenated indoles
30
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
32
Oxygen atoms
34
in position 2
Applicants:
MEDICAL INFORMATION SERVICES, INC. [JP/JP]; 13-21, Shintomi 1-chome Chuo-ku Tokyo 104-0041, JP (AT, BE, CA, CH, CN, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, JP, KR, LU, MC, NL, PT, SE)
KONDO, Hisao [JP/JP]; JP (UsOnly)
HIGASHIKAWA, Tetsuro [JP/JP]; JP (UsOnly)
KUBO, Akinari [JP/JP]; JP (UsOnly)
SAITO, Naoki [JP/JP]; JP (UsOnly)
Inventors:
KONDO, Hisao; JP
HIGASHIKAWA, Tetsuro; JP
KUBO, Akinari; JP
SAITO, Naoki; JP
Agent:
TAKINO, Hideo ; Hiroo SK Building, 4th floor 36-13, Ebisu 2-chome Shibuya-ku Tokyo 150-0013, JP
Priority Data:
9/11123628.04.1997JP
9/20927804.08.1997JP
Title (EN) PROCESS FOR PRODUCING KETOPROFEN AND 5-BENZOYL-3-METHYL-2-INDOLINONE
(FR) PROCEDE SERVANT A PREPARER KETOPROFENE ET 5-BENZOYLE-3-METHYLE-2-INDOLINONE
Abstract:
(EN) A process for producing ketoprofen by benzoylating 3-methyl-2-indolinone with a benzoyl halide, cleaving the amido bond forming the five-membered ring moiety of the formed 5-benzoyl-3-methyl-2-indolinone with a basic compound and replacing an aromatic amino group of the formed compound with a hydrogen atom. A very high yield of ketoprofen can be obtained through ordinary steps, which are short as a whole, without using chemicals of an extremely high toxicity such as cyanides or chemicals of a low handleability, such as liquid ammonia.
(FR) Procédé servant à préparer kétoprofène par benzoylation de 3-méthyle-2-indolinone avec un halogénure de benzoyle, par clivage de la liaison amido constituant la fraction de noyau à cinq éléments de 5-benzoyle-3-méthyle-2-indolinone obtenue avec un composé basique et par remplacement d'un groupe amino aromatique du composé obtenu par un atome d'hydrogène. On peut obtenir un rendement très important de kétoprofène par l'intermédiaire d'étapes ordinaires, courtes dans leur ensemble, sans utiliser de produits chimiques présentant une toxicité extrêmement élevée, tels que des cyanures, ou des produits chimiques peu maniables, tels que de l'ammoniac liquide.
front page image
Designated States: CA, CN, JP, KR, US
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
KR1020010012131EP0990637JP3347745CN1253543CA2288125