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1. (WO1998048830) METHOD FOR PROMOTING MYOGENESIS USING OSTEOGENIC PROTEINS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/048830 International Application No.: PCT/US1998/008466
Publication Date: 05.11.1998 International Filing Date: 27.04.1998
Chapter 2 Demand Filed: 24.11.1998
IPC:
A61K 38/18 (2006.01) ,C12N 5/077 (2010.01) ,A61K 38/00 (2006.01) ,A61K 48/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
18
Growth factors; Growth regulators
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
077
Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applicants:
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US/US]; Suite 300 3700 Market Street Philadelphia, PA 19104, US (AT, AU, BE, CA, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, JP, LU, MC, NL, PT, SE)
EMERSON, Charles, P. [US/US]; US (UsOnly)
BORYCKI, Anne-Gaelle [US/US]; US (UsOnly)
BRUNK, Brian [US/US]; US (UsOnly)
Inventors:
EMERSON, Charles, P.; US
BORYCKI, Anne-Gaelle; US
BRUNK, Brian; US
Agent:
REED, Janet, E. ; Dann, Dorfman, Herrell and Skillman Suite 720 1601 Market Street Philadelphia, PA 19103-2307, US
Priority Data:
60/045,01228.04.1997US
60/058,22509.09.1997US
Title (EN) METHOD FOR PROMOTING MYOGENESIS USING OSTEOGENIC PROTEINS
(FR) PROCEDES DESTINES A FAVORISER LA MYOGENESE EN UTILISANT UNE PROTEINE OSTEOGENIQUE
Abstract:
(EN) Methods and compositions are provided for stimulating lineage commitment of adult or embryonic myogenic stem cells. The methods comprise treating the cells with the osteogenic protein, OP-1, at a concentration effective to induce myogenesis of stem cells. The methods are useful for therapeutic purposes in embryonic development and in repair/regeneration of mature muscle.
(FR) L'invention concerne des procédés et des compositions destinés à stimuler l'obligation de lignage de cellules myogènes souches adultes ou embryonnaires. Ces procédés consistent à traiter les cellules avec la protéine ostéogénique, OP-1, à une concentration suffisante pour induire la myogenèse des cellules souches. Ces procédés ont des fins thérapeutiques pour le développement embryonnaire et pour la réparation/régénération d'un muscle mature.
Designated States: AU, CA, JP, US
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1998072605