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1. (WO1998048829) A VERTEBRATE LENS OBTAINED FROM AN ECTODERMAL CELL AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/048829 International Application No.: PCT/US1998/008592
Publication Date: 05.11.1998 International Filing Date: 29.04.1998
Chapter 2 Demand Filed: 30.11.1998
IPC:
A61K 38/00 (2006.01) ,A61K 38/17 (2006.01) ,A61K 48/00 (2006.01) ,A61L 27/54 (2006.01) ,C07K 14/82 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
50
Materials characterised by their function or physical properties
54
Biologically active materials, e.g. therapeutic substances
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
82
Translation products from oncogenes
Applicants:
THE ROCKEFELLER UNIVERSITY [US/US]; 1230 York Avenue New York, NY 10021-6399, US
NEW YORK UNIVERSITY [US/US]; 70 Washington Square South New York, NY 10012, US
Inventors:
LANG, Richard, A.; US
HEMMATI-BRIVANLOU, Ali; US
ALTMANN, Curtis, R.; US
CHOW, Robert, L.; US
Agent:
DAVIS, Michael, D. ; Klauber & Jackson 411 Hackensack Avenue Hackensack, NJ 07601, US
Priority Data:
08/846,46301.05.1997US
Title (EN) A VERTEBRATE LENS OBTAINED FROM AN ECTODERMAL CELL AND METHODS OF USE THEREOF
(FR) CRISTALLIN DE VERTEBRE OBTENU A PARTIR D'UNE CELLULE ECTODERMIQUE ET PROCEDES D'UTILISATION DE CELUI-CI
Abstract:
(EN) The present invention provides a vertebrate lens produced by selectively inducing lens development in vertebrate ectodermal cells. The vertebrate lenses of the present invention can be produced ectopically in a reliable manner, thereby providing an abundant source of vertebrate lenses for use in lens transplantation, as well as other medical procedures. Included are methods of using the lenses produced by the present invention. Also included are methods of treating a vertebrate with a defect in its lens development pathway, and related pharmaceutical compositions for such treatment. In addition, methods of identifying an agent that selectively induces the formation of a lens without inducing the formation of neural tissue are disclosed.
(FR) La présente invention a trait à un cristallin de vertébré produit par provocation sélective du développement du cristallin dans des cellules ectodermiques de vertébrés. Les cristallins de vertébrés de la présente invention peuvent être produits ectopiquement de façon fiable, ce qui permet d'obtenir une source abondante de cristallins de vertébrés, utiles pour des transplantations de cristallin ainsi que pour d'autres actes médicaux. L'invention se réfère à des procédés d'utilisation de cristallins produits selon la présente invention. L'invention a également trait à des méthodes de traitement d'un vertébré présentant une malformation de voie de développement du cristallin, et à des compositions pharmaceutiques associées destinées à ces traitements. En outre, des procédés permettant d'identifier un agent qui provoque de façon sélective la formation d'un cristallin sans provoquer de formation de tissu neuronal sont également décrits.
Designated States: AU, CA, JP
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1998072645