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1. (WO1998048827) GENES CODING PROTEINS FOR EARLY LIVER DEVELOPMENT AND THEIR USE IN DIAGNOSING AND TREATING LIVER DISEASE

Pub. No.:    WO/1998/048827    International Application No.:    PCT/US1998/008656
Publication Date: Fri Nov 06 00:59:59 CET 1998 International Filing Date: Fri May 01 01:59:59 CEST 1998
IPC: A61K 38/00
C07K 14/47
C07K 16/18
Applicants: MISHRA, Lopa
Inventors: MISHRA, Lopa
Title: GENES CODING PROTEINS FOR EARLY LIVER DEVELOPMENT AND THEIR USE IN DIAGNOSING AND TREATING LIVER DISEASE
Abstract:
Early developing stage-specific liver proteins and the genes coding for them that have been isolated and sequenced are provided, and these genes and proteins can be utilized to diagnose and/or treat a wide variety of liver disorders and other ailments. Included in the proteins identified and isolated in the present invention are the proteins known as elf 1-3, liyor-1 (145), pk, protein 106, and praja-1, along with the nucleic acid sequences coding for these and other proteins, and antibodies may be raised to peptides derived from these proteins. Since the early developing liver proteins of the invention arise during embryogenesis when the liver and other organs are in transition from an undifferentiated state to a differentiated one, these proteins are involved in tissue differentiation and thus can be utilized in methods of diagnosing and treating a variety of liver diseases and other disorders including those relating to oncogenesis and tissue repair. Accordingly, the isolated early developing liver proteins in accordance with the present invention should have implications for diagnosis and treatment of a range of diseases from end stage cirrhosis to hepatocellular carcinoma and many other disease conditions.