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1. (WO1998048826) INHIBITION OF NITRIC OXIDE SYNTHASE BY AMINO ACIDS AND DIPEPTIDES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/048826 International Application No.: PCT/US1998/007037
Publication Date: 05.11.1998 International Filing Date: 08.04.1998
Chapter 2 Demand Filed: 12.11.1998
IPC:
A61K 38/05 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
05
Dipeptides
Applicants:
NORTHWESTERN UNIVERSITY [US/US]; 1801 Maple Avenue Evanston, IL 60201, US (AT, AU, BE, CA, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
SILVERMAN, Richard, B. [US/US]; US (UsOnly)
HUANG, Hui [CN/US]; US (UsOnly)
ZHANG, Henry, Q. [CN/US]; US (UsOnly)
Inventors:
SILVERMAN, Richard, B.; US
HUANG, Hui; US
ZHANG, Henry, Q.; US
Agent:
HEFNER, M., Daniel; Leydig, Voit & Mayer, Ltd. Suite 4900 Two Prudential Plaza 180 North Stetson Chicago, IL 60601-6780, US
Priority Data:
60/045,19230.04.1997US
60/062,66808.10.1997US
Title (EN) INHIBITION OF NITRIC OXIDE SYNTHASE BY AMINO ACIDS AND DIPEPTIDES
(FR) INHIBITION DE LA MONOXYDE D'AZOTE SYNTHETASE PAR DES ACIDES AMINES ET DES PEPTIDES
Abstract:
(EN) Methods and compositions for inhibiting at least one isoform of nitric oxide synthase are provided. Pharmaceutical compositions include derivatives of arginine as well as dipeptides and dipeptide analogs that contain nitroarginine or another unnatural amino acid. Compositions can be used to selectively inhibit particular isoforms of nitric oxide synthase.
(FR) L'invention concerne des méthodes et des compositions qui inhibent au moins une isoforme de la monoxyde d'azote synthétase. Les compositions pharmaceutiques renferment des dérivés de l'arginine, ainsi que des dipeptides et des analogues de dipeptides contenant de la nitro-arginine ou un autre acide aminé non naturel. Elles peuvent être utilisées pour inhiber sélectivement des isoformes particulières de la monoxyde d'azote synthétase.
Designated States: AU, CA, US
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1998072463