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Machine translation
1. (WO1998048822) IMPROVED METHODS FOR PROCESSING ACTIVATED PROTEIN C
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/048822    International Application No.:    PCT/US1998/008384
Publication Date: 05.11.1998 International Filing Date: 24.04.1998
Chapter 2 Demand Filed:    23.11.1998    
IPC:
A61K 38/48 (2006.01)
Applicants: ELI LILLY AND COMPANY [US/US]; Lilly Corporate Center, Indianapolis, IN 46285 (US) (AL, AM, AU, AZ, BA, BB, BF, BG, BJ, BR, BY, CA, CF, CG, CI, CM, CN, CU, CZ, EE, GA, GE, GH, GM, GN, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LV, MD, MG, MK, ML, MN, MR, MW, MX, NE, NO, NZ, PL, RO, RU, SD, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW only).
BAKER, Jeffrey, Clayton [US/US]; (US) (For US Only).
CARLSON, Andrew, David [US/US]; (US) (For US Only).
HUANG, Lihua [CN/US]; (US) (For US Only).
SHELIGA, Theodore, Arsay [US/US]; (US) (For US Only)
Inventors: BAKER, Jeffrey, Clayton; (US).
CARLSON, Andrew, David; (US).
HUANG, Lihua; (US).
SHELIGA, Theodore, Arsay; (US)
Agent: CALTRIDER, Steven, P.; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285 (US)
Priority Data:
60/045,255 28.04.1997 US
Title (EN) IMPROVED METHODS FOR PROCESSING ACTIVATED PROTEIN C
(FR) PERFECTIONNEMENT DU TRAITEMENT DE LA PROTEINE C ACTIVEE
Abstract: front page image
(EN)The present invention is broadly directed to a method for reducing autodegradation of activated protein C during processing and purification. The present invention provides aqueous activated protein C solutions and an improved method of processing of such solutions, comprising conducting such processing at an ionic strength of greater than 150 mM and at pH of about 5.5 to less than 6.3.
(FR)La présente invention concerne généralement un procédé permettant de réduire le niveau de dégradation spontanée de la protéine C activée pendant le traitement et la purification. L'invention concerne notamment des solutions aqueuses de protéine C et un perfectionnement du procédé permettant de traiter de telles solutions, et notamment de réaliser un tel traitement avec une force ionique supérieure à 150 mM pour un pH d'environ 5,5 n'excédant pas 6,3.
Designated States: AL, AM, AU, AZ, BA, BB, BG, BR, BY, CA, CN, CU, CZ, EE, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, RO, RU, SD, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)