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1. (WO1998048822) IMPROVED METHODS FOR PROCESSING ACTIVATED PROTEIN C

Pub. No.:    WO/1998/048822    International Application No.:    PCT/US1998/008384
Publication Date: Fri Nov 06 00:59:59 CET 1998 International Filing Date: Sat Apr 25 01:59:59 CEST 1998
IPC: A61K 38/48
Applicants: ELI LILLY AND COMPANY
BAKER, Jeffrey, Clayton
CARLSON, Andrew, David
HUANG, Lihua
SHELIGA, Theodore, Arsay
Inventors: BAKER, Jeffrey, Clayton
CARLSON, Andrew, David
HUANG, Lihua
SHELIGA, Theodore, Arsay
Title: IMPROVED METHODS FOR PROCESSING ACTIVATED PROTEIN C
Abstract:
The present invention is broadly directed to a method for reducing autodegradation of activated protein C during processing and purification. The present invention provides aqueous activated protein C solutions and an improved method of processing of such solutions, comprising conducting such processing at an ionic strength of greater than 150 mM and at pH of about 5.5 to less than 6.3.