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1. (WO1998048816) AMINOSUGAR, GLYCOSAMINOGLYCAN OR GLYCOSAMINOGLYCAN-LIKE COMPOUNDS, AND S-ADENOSYLMETHIONINE

Pub. No.:    WO/1998/048816    International Application No.:    PCT/US1998/007561
Publication Date: Fri Nov 06 00:59:59 CET 1998 International Filing Date: Sat Apr 18 01:59:59 CEST 1998
IPC: A61K 45/06
Applicants: NUTRAMAX LABORATORIES, INC.
Inventors: HENDERSON, Robert, W.
HENDERSON, Todd
HAMMAD, Tarek
Title: AMINOSUGAR, GLYCOSAMINOGLYCAN OR GLYCOSAMINOGLYCAN-LIKE COMPOUNDS, AND S-ADENOSYLMETHIONINE
Abstract:
A composition for the protection, treatment and repair and for reducing the inflammation of connective tissue in mammals and a method for the protection, treatment of connective tissue in mammals by the administration of the composition. The composition includes at least two compounds selected from S-Adenosylmethionine (SAM), an aminosugar selected from the group consisting of glucosamine, glucosamine salts, glucosamine hydrochloride, galactosamine, N-acetylglucosamine, and fragments, mixtures or salts thereof, and a glycosaminoglycan or glycosaminoglycan-like compound selected from the group consisting of chondroitin, chondroitin salts, hyaluronic acid, glucaronic acid, iduronic acid, keratan sulfate, keratin sulfate, heparan sulfate, dermatin sulfate, PPS, sodium PPS, calcium PPS, oversulfated GAGs, and fragments, salts, and mixtures thereof. The composition optionally includes manganese which promotes the production of connective tissue matrix. The composition also optionally includes methyl donors or methyl donor cofactors, such as vitamin B12, vitamin B6, folic acid, dimethylglycine or trimethylglycine, and betaine.