Search International and National Patent Collections

1. (WO1998048805) PHARMACEUTICAL COMPOSITION FOR SUPRESSING TYPE 2 HELPER T CELL IMMUNE RESPONSE

Pub. No.:    WO/1998/048805    International Application No.:    PCT/JP1998/001841
Publication Date: Fri Nov 06 00:59:59 CET 1998 International Filing Date: Thu Apr 23 01:59:59 CEST 1998
IPC: A61K 31/4745
Applicants: SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
JAPAN ENERGY CORPORATION
OCHI, Hiroshi
WATANABE, Takamasa
TOMIZAWA, Hideyuki
GOTO, Yuso
Inventors: OCHI, Hiroshi
WATANABE, Takamasa
TOMIZAWA, Hideyuki
GOTO, Yuso
Title: PHARMACEUTICAL COMPOSITION FOR SUPRESSING TYPE 2 HELPER T CELL IMMUNE RESPONSE
Abstract:
A pharmaceutical composition for suppressing Th2 type immune response comprising as active ingredient a compound represented by formula (1), wherein R1 is alkyl, cycloalkyl, hydroxyalkyl, acyloxyalkyl, aralkyl, substituted aralkyl, phenyl, or substituted phenyl; R2 is H or alkyl; R3 is alkoxy, halogen or alkyl; n is 0 to 2; specifically 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine, or a pharmaceutically acceptable acid salt thereof, and a method for treating or preventing a disease caused by abnormal activation of Th2 type immune response, such as asthma, allergic dermatitis, allergic rhinitis or systemic lupus erythematosus, which comprises administering a therapeutically effective amount of the compoud (1) to a patient in need thereof.