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1. (WO1998048805) PHARMACEUTICAL COMPOSITION FOR SUPRESSING TYPE 2 HELPER T CELL IMMUNE RESPONSE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/048805    International Application No.:    PCT/JP1998/001841
Publication Date: 05.11.1998 International Filing Date: 22.04.1998
Chapter 2 Demand Filed:    05.10.1998    
IPC:
A61K 31/4745 (2006.01)
Applicants: SUMITOMO PHARMACEUTICALS COMPANY, LIMITED [JP/JP]; 2-8, Dosho-machi 2-chome, Chuo-ku, Oska-shi, Osaka 541-0045 (JP) (AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, GW, HU, ID, IE, IL, IS, IT, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW only).
JAPAN ENERGY CORPORATION [JP/JP]; 10-1, Toranomon 2-chome, Minato-ku, Tokyo 105-0001 (JP) (AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, GW, HU, ID, IE, IL, IS, IT, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW only).
OCHI, Hiroshi [JP/JP]; (JP) (For US Only).
WATANABE, Takamasa [JP/JP]; (JP) (For US Only).
TOMIZAWA, Hideyuki [JP/JP]; (JP) (For US Only).
GOTO, Yuso [JP/JP]; (JP) (For US Only)
Inventors: OCHI, Hiroshi; (JP).
WATANABE, Takamasa; (JP).
TOMIZAWA, Hideyuki; (JP).
GOTO, Yuso; (JP)
Agent: AOYAMA, Tamotsu; Aoyama & Partners, IMP Building, 3-7, Shiromi 1-chome, Chuo-ku, Osaka-shi, Osaka 540-0001 (JP)
Priority Data:
9/123146 25.04.1997 JP
Title (EN) PHARMACEUTICAL COMPOSITION FOR SUPRESSING TYPE 2 HELPER T CELL IMMUNE RESPONSE
(FR) COMPOSITION PHARMACEUTIQUE PERMETTANT DE SUPPRIMER LA REACTION IMMUNITAIRE DES LYMPHOCYTES T AUXILIAIRES DE TYPE 2
Abstract: front page image
(EN)A pharmaceutical composition for suppressing Th2 type immune response comprising as active ingredient a compound represented by formula (1), wherein R1 is alkyl, cycloalkyl, hydroxyalkyl, acyloxyalkyl, aralkyl, substituted aralkyl, phenyl, or substituted phenyl; R2 is H or alkyl; R3 is alkoxy, halogen or alkyl; n is 0 to 2; specifically 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine, or a pharmaceutically acceptable acid salt thereof, and a method for treating or preventing a disease caused by abnormal activation of Th2 type immune response, such as asthma, allergic dermatitis, allergic rhinitis or systemic lupus erythematosus, which comprises administering a therapeutically effective amount of the compoud (1) to a patient in need thereof.
(FR)Cette invention se rapporte à une composition pharmaceutique qui permet de supprimer la réaction immunitaire des lymphocytes T auxiliaires de type 2, ladite composition comportant en tant qu'ingrédient actif un composé représenté par la formule (1), dans laquelle R1 est alkyle, cycloalkyle, hydroxyalkyle, acyloxyalkyle, aralkyle, aralkyle substitué, phényle ou phényle substitué; R2 est H ou alkyle; R3 est alcoxy, halogène ou alkyle; n est égal à 0, 1 ou 2; ledit composé étant spécifiquement 1-(2-méthylpropyl)-1H-imidazo[4,5-c]quinoline-4-amine. L'invention se rapporte également à un sel pharmaceutiquement acceptable de ce composé et à un procédé de traitement ou de prévention des maladies provoquées par une activation anormale de la réaction immunitaire des lymphocytes T auxiliaires de type 2, telles que l'asthme, l'eczéma constitutionnel, la rhinite allergique ou le lupus érythémateux disséminé, ledit procédé consistant à administrer une quantité thérapeutiquement efficace du composé (1) à un patient justiciable d'un tel traitement.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)