Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO1998048801) 2-AZABICYCLO COMPOUNDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/048801 International Application No.: PCT/JP1998/001817
Publication Date: 05.11.1998 International Filing Date: 21.04.1998
Chapter 2 Demand Filed: 13.05.1998
IPC:
C07D 209/52 (2006.01) ,C07D 453/06 (2006.01) ,C07D 471/08 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
52
condensed with a ring other than six-membered
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
453
Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
06
containing iso-quinuclidine ring systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
08
Bridged systems
Applicants:
SUMITOMO PHARMACEUTICALS CO., LTD. [JP/JP]; 2-8, Doshomachi 2-chome Chuo-ku Osaka-shi Osaka 541-8510, JP (AT, BE, CA, CH, CN, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, JP, KR, LU, MC, NL, PT, SE)
NISHIHARA, Toshio [JP/JP]; JP (UsOnly)
TOYODA, Tomohiro [JP/JP]; JP (UsOnly)
Inventors:
NISHIHARA, Toshio; JP
TOYODA, Tomohiro; JP
Agent:
NAKAMURA, Toshio; Legal & Patent Dept. Sumitomo Pharmaceuticals Co., Ltd. 1-98, Kasugadenaka 3-chome Konohana-ku, Osaka-shi Osaka 554-0022, JP
Priority Data:
9/12328026.04.1997JP
Title (EN) 2-AZABICYCLO COMPOUNDS
(FR) COMPOSES 2-AZABICYCLO
Abstract:
(EN) 2-Azabicyclo compounds represented by general formula (1) or pharmaceutically acceptable salts thereof, which are nicotinic acetylcholine agonists and useful as remedies for diseases caused by central nerve degeneration such as Alzheimer's disease and Parkinson's disease and as analgesics. In said formula, R1 represents hydrogen or alkyl; one of R2 and R3 represents optionally substituted, nitrogen-containing heteroaryl, while another represents hydrogen, alkyl, alkenyl, alkynyl or aralkyl; n is 1, 2 or 3; and one of X1 and X2 represents hydrogen while another represents hydrogen, hydroxy, halogeno, alkoxy, alkenyloxy or alkynyloxy, or X1 and X2 may form together with the solid line a double bond.
(FR) Cette invention se rapporte à des composés 2-azabicyclo représentés par la formule générale (1) ou à des sels pharmaceutiquement acceptables de ces composés, qui sont des agonistes de l'acétylcholine nicotinique et s'avèrent utiles en tant que remèdes destinés à des maladies provoquées par la dégénérescence du système nerveux central telles que la maladie d'Alzheimer et la maladie de Parkinson, et en tant qu'analgésiques. Dans la formule (I), R1 est hydrogène ou alkyle; l'un des deux groupes que sont R2 et R3 est hétéroaryle contenant de l'azote et éventuellement substitué, l'autre étant hydrogène, alkyle, alkényle, alkynyle ou aralkyle; n est égal à 1, 2 ou 3 et l'un des deux groupes que sont X1 et X2 est hydrogène tandis que l'autre est hydrogène, hydroxy, halogéno, alcoxy, alkényloxy ou alkynyloxy, ou bien X1 et X2 forment, avec la ligne continue, une double liaison.
front page image
Designated States: CA, CN, JP, KR, US
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
EP0978280CA2287223