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1. (WO1998048800) ANTITHROMBOTIC AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/048800 International Application No.: PCT/US1998/008755
Publication Date: 05.11.1998 International Filing Date: 30.04.1998
Chapter 2 Demand Filed: 20.11.1998
IPC:
A61K 31/4184 (2006.01) ,A61K 31/4196 (2006.01) ,A61K 31/497 (2006.01) ,C07D 235/18 (2006.01) ,C07D 403/12 (2006.01) ,C07D 521/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
4184
condensed with carbocyclic rings, e.g. benzimidazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4196
1,2,4-Triazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4965
Non-condensed pyrazines
497
containing further heterocyclic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
235
Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
02
condensed with carbocyclic rings or ring systems
04
Benzimidazoles; Hydrogenated benzimidazoles
18
with aryl radicals directly attached in position 2
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
521
Heterocyclic compounds containing unspecified hetero rings
Applicants:
BASTIAN, Jolie, A. [US/US]; US (UsOnly)
CHIRGADZE, Nickolay Y. [RU/US]; US (UsOnly)
DENNEY, Michael, L. [US/US]; US (UsOnly)
FISHER, Matthew, J. [US/US]; US (UsOnly)
FOGLESONG, Robert, J. [US/US]; US (UsOnly)
HARPER, Richard, W. [US/US]; US (UsOnly)
JOHNSON, Mary, G. [US/US]; US (UsOnly)
KLIMKOWSKI, Valentine, J. [US/US]; US (UsOnly)
LIN, Ho-Shen [US/US]; US (UsOnly)
LYNCH, Michael, P. [US/US]; US (UsOnly)
MCCOWAN, Jefferson, R. [US/US]; US (UsOnly)
MILLER, Shawn, C. [US/US]; US (UsOnly)
MULLANEY, Jeffrey, T. [US/US]; US (UsOnly)
RICHETT, Michael, E. [US/US]; US (UsOnly)
SALL, Daniel, J. [US/US]; US (UsOnly)
SMITH, Gerald, F. [US/US]; US (UsOnly)
TAKEUCHI, Kumiko [US/US]; US (UsOnly)
TINSLEY, Jennifer, M. [US/US]; US (UsOnly)
WILEY, Michael, R. [US/US]; US (UsOnly)
ZHANG, Minsheng [CN/US]; US (UsOnly)
ELI LILLY AND COMPANY [US/US]; Lilly Corporate Center Indianapolis, IN 46285, US (AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, GW, HU, ID, IE, IL, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW)
Inventors:
BASTIAN, Jolie, A.; US
CHIRGADZE, Nickolay Y.; US
DENNEY, Michael, L.; US
FISHER, Matthew, J.; US
FOGLESONG, Robert, J.; US
HARPER, Richard, W.; US
JOHNSON, Mary, G.; US
KLIMKOWSKI, Valentine, J.; US
LIN, Ho-Shen; US
LYNCH, Michael, P.; US
MCCOWAN, Jefferson, R.; US
MILLER, Shawn, C.; US
MULLANEY, Jeffrey, T.; US
RICHETT, Michael, E.; US
SALL, Daniel, J.; US
SMITH, Gerald, F.; US
TAKEUCHI, Kumiko; US
TINSLEY, Jennifer, M.; US
WILEY, Michael, R.; US
ZHANG, Minsheng; US
Agent:
JACKSON, Thomas, E. ; Eli Lilly and Company Lilly Corporate Center Indianapolis, IN 46285, US
Priority Data:
60/045,33501.05.1997US
Title (EN) ANTITHROMBOTIC AGENTS
(FR) AGENTS ANTITHROMBOTIQUES
Abstract:
(EN) This application relates to novel compounds of formula (I), and their pharmaceutically acceptable salts, as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula (I), and the use of the compounds of formula (I) as thrombin inhibitors.
(FR) Nouveaux composés de formule (I) (et leurs sels acceptables sur le plan pharmaceutique), tels que définis dans le descriptif, procédés et intermédiaires utiles pour leur préparation, compositions pharmaceutiques contenant lesdits composés de formule (I), et utilisation desdits composés en tant qu'inhibiteurs de thrombine.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)