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1. (WO1998048798) ANTITHROMBOTIC AGENTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/048798 International Application No.: PCT/US1998/008700
Publication Date: 05.11.1998 International Filing Date: 30.04.1998
Chapter 2 Demand Filed: 20.11.1998
IPC:
C07D 333/56 (2006.01) ,C07D 409/10 (2006.01) ,C07D 409/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
333
Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
50
condensed with carbocyclic rings or ring systems
52
Benzo [b] thiophenes; Hydrogenated benzo [b] thiophenes
54
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
56
Radicals substituted by oxygen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02
containing two hetero rings
10
linked by a carbon chain containing aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
Applicants:
ELI LILLY AND COMPANY [US/US]; Lilly Corporate Center Indianapolis, IN 46285, US (AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, GW, HU, ID, IE, IL, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW)
CHIRGADZE, Nickolay Yuri [RU/US]; US (UsOnly)
HARPER, Richard, Waltz [US/US]; US (UsOnly)
KOHN, Todd, Jonathan [US/US]; US (UsOnly)
LIN, Ho-Shen [US/US]; US (UsOnly)
MCCOWAN, Jefferson, R. [US/US]; US (UsOnly)
PALKOWITZ, Alan, David [US/US]; US (UsOnly)
SALL, Daniel, Jon [US/US]; US (UsOnly)
SMITH, Gerald, Floyd [US/US]; US (UsOnly)
TAKEUCHI, Kumiko [US/US]; US (UsOnly)
WILEY, Michael, Robert [US/US]; US (UsOnly)
ZHANG, Minsheng [CN/US]; US (UsOnly)
Inventors:
CHIRGADZE, Nickolay Yuri; US
HARPER, Richard, Waltz; US
KOHN, Todd, Jonathan; US
LIN, Ho-Shen; US
MCCOWAN, Jefferson, R.; US
PALKOWITZ, Alan, David; US
SALL, Daniel, Jon; US
SMITH, Gerald, Floyd; US
TAKEUCHI, Kumiko; US
WILEY, Michael, Robert; US
ZHANG, Minsheng; US
Agent:
JACKSON, Thomas, E. ; Eli Lilly and Company Lilly Corporate Center Indianapolis, IN 46285, US
Priority Data:
60/045,17330.04.1997US
Title (EN) ANTITHROMBOTIC AGENTS
(FR) AGENTS ANTITHROMBOTIQUES
Abstract:
(EN) This application relates to novel compounds of formula (I) (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula (I), and the use of the compounds of formula (I) as thrombin inhibitors.
(FR) La présente invention concerne de nouveaux composés représentés par la formule (I) (et leurs sels pharmaceutiquement acceptables), tels que définis dans la description, des procédés et des intermédiaires pour leur préparation. La présente invention concerne également des formulations pharmaceutiques comprenant les nouveaux composés, et leur utilisation comme inhibiteurs de thrombine.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0993300US6284756JP2001523255 CA2287901AU1998075635