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1. (WO1998048791) SYNTHESIS OF DISCODERMOLIDE AND ANALOGS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/048791 International Application No.: PCT/US1998/008670
Publication Date: 05.11.1998 International Filing Date: 30.04.1998
Chapter 2 Demand Filed: 26.10.1998
IPC:
C07D 309/30 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
309
Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
16
having one double bond between ring members or between a ring member and a non-ring member
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
30
Oxygen atoms, e.g. delta-lactones
Applicants:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 22nd floor 300 Lakeside Drive Oakland, CA 94612-3550, US (AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, HU, IE, IL, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW)
MYLES, David, C. [US/US]; US (UsOnly)
HARRIED, Scott, S. [US/US]; US (UsOnly)
YANG, Ge [CN/CN]; US (UsOnly)
Inventors:
MYLES, David, C.; US
HARRIED, Scott, S.; US
YANG, Ge; US
Agent:
OLDENKAMP, David, J. ; Oppenheimer Wolff & Donnelly LLP Suite 3800 2029 Century Park East Los Angeles, CA 90067, US
Priority Data:
60/045,21530.04.1997US
Title (EN) SYNTHESIS OF DISCODERMOLIDE AND ANALOGS
(FR) SYNTHESE DE DISCODERMOLIDE ET ANALOGUES
Abstract:
(EN) A method for making discodermolide and analogs thereof. The method utilizes three precursors which correspond to three subparts of discodermolide which are formed by disconnecting the discodermolide carbon backbone at positions C-7 to C-8 and C-15 to C-16. Coupling of the precursors is accomplished using chelation-controlled alkylation.
(FR) La présente invention concerne un procédé de fabrication de discodermolide et d'analogues de ce dernier. Ledit procédé fait appel à trois précurseurs qui correspondent à trois sous-parties du discodermolide que l'on forme en scindant le squelette de carbone du discodermolide entre C-7 et C-8 et entre C-15 et C-16. Le couplage des précurseurs s'effectue par une alkylation à chélation contrôlée.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1998072672