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1. (WO1998048626) METHODS AND COMPOSITIONS FOR ADMINISTERING DNA TO MUCOSAL SURFACES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/048626 International Application No.: PCT/US1998/008704
Publication Date: 05.11.1998 International Filing Date: 30.04.1998
Chapter 2 Demand Filed: 25.11.1998
IPC:
A61K 39/145 (2006.01) ,A61K 39/155 (2006.01) ,A61K 48/00 (2006.01) ,C07K 14/11 (2006.01) ,C07K 14/155 (2006.01) ,C12N 15/87 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
145
Orthomyxoviridae, e.g. influenza virus
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
155
Paramyxoviridae, e.g. parainfluenza virus
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
08
RNA viruses
11
Orthomyxoviridae, e.g. influenza virus
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
08
RNA viruses
15
Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
155
Lentiviridae, e.g. human immunodeficiency virus (HIV), visna-maedi virus, equine infectious anaemia virus
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
87
Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
Applicants:
EMORY UNIVERSITY [US/US]; 2009 Ridgewood Drive Atlanta, GA 30322, US (AT, AU, BE, CA, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, JP, LU, MC, NL, PT, SE)
COMPANS, Richard, W. [US/US]; US (UsOnly)
Inventors:
COMPANS, Richard, W.; US
Agent:
FERBER, Donna, M. ; Greenlee, Winner and Sullivan, P.C. Suite 201 5370 Manhattan Circle Boulder, CO 80303, US
Priority Data:
60/045,10830.04.1997US
Title (EN) METHODS AND COMPOSITIONS FOR ADMINISTERING DNA TO MUCOSAL SURFACES
(FR) PROCEDES ET COMPOSITIONS POUR ADMINISTRATION D'ADN A DES SURFACES MUCOSALES
Abstract:
(EN) The present invention provides an economical, nontraumatic and surprinsingly effective method for producing a desired protein (especially a biologically active protein) or an antigen using nucleic acid molecules encoding the protein or antigen delivered to a mucosal surface of the animal or human. Expression of the antigen coding sequence exposes the immune system of the animal or human to the antigen with the result than an immune response results, especially an antigen-specific IgA response at mucosal surfaces. Desirably, the nucleic acid molecules are formulated with a bioadhesive agent in an amount sufficient to improve adherence to cells at the mucosal surfaces, thereby improving uptake of the nucleic acid molecules.
(FR) La présente invention concerne un procédé économique, non traumatisant et étonnamment efficace, de production d'une protéine désirée (en particulier, une protéine biologiquement active) ou d'un antigène utilisant des molécules d'acide nucléique, codant pour la protéine ou l'antigène administrés à une surface mucosale de l'animal ou de l'homme. Une expression de la séquence codant pour l'antigène expose le système immunitaire de l'animal ou de l'homme à l'antigène provoquant une réponse immunitaire, en particulier, une réponse IgA spécifique à l'antigène, au niveau de surfaces mucosales. Avantageusement, les molécules d'acide nucléique sont formulées avec un agent bioadhésif en quantité suffisante pour améliorer l'adhésion à des cellules au niveau de surfaces mucosales, améliorant ainsi l'apport des molécules d'acide nucléique.
Designated States: AU, CA, JP, US
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1998075637