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1. WO1998037181 - TELOMERASE CATALYTIC SUBUNIT GENE AND ENCODED PROTEIN

Publication Number WO/1998/037181
Publication Date 27.08.1998
International Application No. PCT/US1998/003404
International Filing Date 20.02.1998
Chapter 2 Demand Filed 10.08.1998
IPC
C12N 9/12 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
12transferring phosphorus containing groups, e.g. kinases (2.7)
CPC
C12N 9/1241
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
10Transferases (2.)
12transferring phosphorus containing groups, e.g. kinases (2.7)
1241Nucleotidyltransferases (2.7.7)
Applicants
  • WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH [US]/[US] (AllExceptUS)
  • COUNTER, Christopher, M. [CA]/[US] (UsOnly)
  • MEYERSON, Matthew [US]/[US] (UsOnly)
  • WEINBERG, Robert, A. [US]/[US] (UsOnly)
Inventors
  • COUNTER, Christopher, M.
  • MEYERSON, Matthew
  • WEINBERG, Robert, A.
Agents
  • GRANAHAN, Patricia
Priority Data
60/038,75020.02.1997US
60/047,15120.05.1997US
60/054,54901.08.1997US
60/055,76214.08.1997US
60/064,32230.10.1997US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TELOMERASE CATALYTIC SUBUNIT GENE AND ENCODED PROTEIN
(FR) GENE DE SOUS-UNITE CATALYTIQUE DE TELOMERASE ET PROTEINE CODEE
Abstract
(EN)
Isolated DNA encoding the catalytic subunit of a eukaryotic telomerase holoenzyme, such as the catalytic subunit of a yeast or human telomerase holoenzyme; the RNA transcript, which is expressed in primary human tumors, cancer cell lines and telomerase-positive tissues; and the encoded catalytic subunit protein. Methods of assessing cells for malignancy or an increased likelihood of progression to malignancy and methods of diagnosing or aiding in the diagnosis of development of malignancy in an individual are also described.
(FR)
Cette invention concerne de l'ADN isolé codant la sous-unité catalytique d'une holoenzyme de télomérase eucaryotique telle que la sous-unité catalytique d'une holoenzyme de télomérase humaine ou de levure; le transcript d'ARN qui est exprimé dans des tumeurs humaines primitives, des lignées cellulaires cancéreuses et des tissus télomérase-positifs; et la protéine de sous-unité catalytique codée. L'invention concerne également des procédés qui permettent d'évaluer le caractère malin des cellules ou la probabilité accrue que les cellules deviennent malignes et des méthodes de diagnostic ou facilitant le diagnostic du développement du caractère malin des cellules chez un individu.
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