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1. WO1998035026 - POLYPEPTIDE-POLYMER CONJUGATES HAVING ADDED AND/OR REMOVED ATTACHMENT GROUPS

Publication Number WO/1998/035026
Publication Date 13.08.1998
International Application No. PCT/DK1998/000046
International Filing Date 06.02.1998
Chapter 2 Demand Filed 10.06.1998
IPC
A61K 47/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C11D 3/37 2006.01
CCHEMISTRY; METALLURGY
11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
3Other compounding ingredients of detergent compositions covered in group C11D1/101
16Organic compounds
37Polymers
C11D 3/386 2006.01
CCHEMISTRY; METALLURGY
11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
3Other compounding ingredients of detergent compositions covered in group C11D1/101
16Organic compounds
38Products with no well-defined composition
386Preparations containing enzymes
CPC
A61K 47/56
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
56the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
A61K 47/60
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
56the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
59obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
60the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
C11D 3/37
CCHEMISTRY; METALLURGY
11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
DDETERGENT COMPOSITIONS
3Other compounding ingredients of detergent compositions covered in group C11D1/00
16Organic compounds
37Polymers
C11D 3/386
CCHEMISTRY; METALLURGY
11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
DDETERGENT COMPOSITIONS
3Other compounding ingredients of detergent compositions covered in group C11D1/00
16Organic compounds
38Products with no well-defined composition ; , e.g. natural products
386Preparations containing enzymes ; , e.g. protease, amylase
Applicants
  • NOVO NORDISK A/S [DK]/[DK] (AllExceptUS)
  • VON DER OSTEN, Claus [DK]/[DK] (UsOnly)
  • OLSEN, Arne, Agerlin [DK]/[DK] (UsOnly)
  • ROGGEN, Erwin, Ludo [DK]/[DK] (UsOnly)
Inventors
  • VON DER OSTEN, Claus
  • OLSEN, Arne, Agerlin
  • ROGGEN, Erwin, Ludo
Agents
  • NOVO NORDISK A/S
Common Representative
  • NOVO NORDISK A/S
Priority Data
0135/9706.02.1997DK
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) POLYPEPTIDE-POLYMER CONJUGATES HAVING ADDED AND/OR REMOVED ATTACHMENT GROUPS
(FR) CONJUGATS POLYPEPTIDE-POLYMERE A GROUPES DE FIXATION AJOUTES ET/OU RETIRES
Abstract
(EN)
The present invention relates to polypeptide-polymer conjugates having added and/or removed one or more attachment groups for coupling polymeric molecules on the surface of the polypeptide structure, a method for preparing polypeptide-polymer conjugates of the invention, the use of said conjugated for reducing the immunogenicity and allergenicity and compositions comprising said conjugate.
(FR)
Cette invention a trait à des conjugats polypeptide-polymère à groupe (s) de fixation ajouté (s) et/ou retiré (s), ce ou ces groupes étant destiné (s) à coupler des molécules polymères à la surface de la structure polypeptidique. Elle concerne également un procédé de préparation des conjugats polypeptide-polymère susmentionnés, leur utilisation s'agissant de réduire capacité immunogène et pouvoir allergisant ainsi que des compositions contenant lesdits conjugats.
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