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1. WO1998034596 - BIOCOMPATIBLE COMPOUNDS FOR PHARMACEUTICAL DRUG DELIVERY SYSTEMS

Publication Number WO/1998/034596
Publication Date 13.08.1998
International Application No. PCT/US1998/000074
International Filing Date 04.02.1998
Chapter 2 Demand Filed 04.09.1998
IPC
A61K 9/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
16Agglomerates; Granulates; Microbeadlets
A61K 47/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
CPC
A61K 47/593
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
56the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
59obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
593Polyesters, e.g. PLGA or polylactide-co-glycolide
A61K 9/0075
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
007Pulmonary tract; Aromatherapy
0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy;
0075for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
A61K 9/008
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
007Pulmonary tract; Aromatherapy
0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy;
008comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
A61K 9/1647
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1605Excipients; Inactive ingredients
1629Organic macromolecular compounds
1641obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
1647Polyesters, e.g. poly(lactide-co-glycolide)
Applicants
  • MINNESOTA MINING AND MANUFACTURING COMPANY [US]/[US]
Inventors
  • STEFELY, James, S.
  • SCHULTZ, David, W.
  • SCHALLINGER, Luke, E.
  • PERMAN, Craig, A.
  • LEACH, Chester, L.
  • DUAN, Daniel, C.
Agents
  • RINGSRED, Ted, K.
  • VOSSIUS & PARTNER
Priority Data
08/797,80307.02.1997US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BIOCOMPATIBLE COMPOUNDS FOR PHARMACEUTICAL DRUG DELIVERY SYSTEMS
(FR) COMPOSES BIOCOMPATIBLES DESTINES A DES SYSTEMES D'APPORT DE MEDICAMENTS
Abstract
(EN)
Methods, compounds, and medicinal formulations utilizing biocompatible polymers for delivery of a drug, particularly for solubilizing, stabilizing and/or providing sustained release of drug from topical, implantable, and inhalation systems. Many of the methods, compounds, and medicinal formulations are particularly suitable for oral and/or nasal inhalation and use polymers of the formula -[X-R1-C(O)]- wherein each R1 is an independently selected organic group that links the -X- group to the carbonyl group, and each X is independently oxygen, sulfur, or catenary nitrogen.
(FR)
L'invention concerne des procédés, composés et formulations médicinales dans lesquels on utilise des polymères biocompatibles pour l'apport d'un médicament, notamment pour solubiliser, stabiliser et/ou procurer une libération prolongée de médicament à partir de systèmes topiques, implantables et d'inhalation. Beaucoup de ces procédés, composés et formulations médicinales sont appropriés à une inhalation orale et/ou nasale, et à une utilisation de polymères de la formule -[X-R1-C(O)]- dans laquelle chaque R1 représente un groupe organique, choisi indépendamment et qui lie le groupe -X- au groupe carbonyle, chaque X représentant indépendamment oxygène, soufre ou azote caténaire.
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