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1. WO1998034584 - COMPOUNDS AND METHOD FOR PREPARING SUBSTITUTED 4-PHENYL-4-CYANOCYCLOHEXANOIC ACIDS

Publication Number WO/1998/034584
Publication Date 13.08.1998
International Application No. PCT/US1998/002749
International Filing Date 12.02.1998
Chapter 2 Demand Filed 28.08.1998
IPC
C07C 253/30 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
253Preparation of carboxylic acid nitriles
30by reactions not involving the formation of cyano groups
C07C 255/46 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
255Carboxylic acid nitriles
45having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
46to carbon atoms of non-condensed rings
C07D 303/48 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
303Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
02Compounds containing oxirane rings
48with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
CPC
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
C07C 253/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
253Preparation of carboxylic acid nitriles
30by reactions not involving the formation of cyano groups
C07C 2601/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
06with a five-membered ring
08the ring being saturated
C07C 2601/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
12with a six-membered ring
14The ring being saturated
C07D 303/48
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
303Compounds containing three-membered rings having one oxygen atom as the only ring heteroatom
02Compounds containing oxirane rings
48with hetero atoms or with carbon atoms having three bonds to hetero atoms; with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
Applicants
  • SMITHKLINE BEECHAM CORPORATION [US]/[US] (AllExceptUS)
  • ALLEN, Andrew [US]/[US] (UsOnly)
  • DIEDERICH, Ann, Marie [US]/[US] (UsOnly)
  • LIU, Li [US]/[US] (UsOnly)
  • MENDELSON, Wilford [US]/[US] (UsOnly)
Inventors
  • ALLEN, Andrew
  • DIEDERICH, Ann, Marie
  • LIU, Li
  • MENDELSON, Wilford
Agents
  • KANAGY, James, M.
Priority Data
60/037,60812.02.1997US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOUNDS AND METHOD FOR PREPARING SUBSTITUTED 4-PHENYL-4-CYANOCYCLOHEXANOIC ACIDS
(FR) COMPOSES ET PROCEDE DE PREPARATION D'ACIDES 4-PHENYL-4-CYANOCYCLOHEXANOIQUES SUBSTITUES
Abstract
(EN)
This invention relates to a method of preparing a compound of formula (I) by treating a compound of formula (II) with lithium bromide, magnesium bromide and the like.
(FR)
L'invention concerne un procédé de préparation d'un composé de formule (I). Ce procédé consiste à traiter un composé de formule (II) avec du bromure de lithium, du bromure de magnésium, et similaire.
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