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1. WO1998033771 - HYDROQUINONE DERIVATIVES

Publication Number WO/1998/033771
Publication Date 06.08.1998
International Application No. PCT/JP1998/000325
International Filing Date 26.01.1998
Chapter 2 Demand Filed 24.08.1998
IPC
C07D 213/74 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
72Nitrogen atoms
74Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
C07D 239/42 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
32One oxygen, sulfur or nitrogen atom
42One nitrogen atom
C07D 295/088 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
295Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
04with substituted hydrocarbon radicals attached to ring nitrogen atoms
08substituted by singly bound oxygen or sulfur atoms
084with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
088to an acyclic saturated chain
C07D 295/092 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
295Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
04with substituted hydrocarbon radicals attached to ring nitrogen atoms
08substituted by singly bound oxygen or sulfur atoms
084with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
092with aromatic radicals attached to the chain
CPC
C07D 213/74
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
72Nitrogen atoms
74Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
C07D 239/42
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
32One oxygen, sulfur or nitrogen atom
42One nitrogen atom
C07D 295/088
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
295Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
04with substituted hydrocarbon radicals attached to ring nitrogen atoms
08substituted by singly bound oxygen or sulfur atoms
084with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
088to an acyclic saturated chain
Applicants
  • SENJU PHARMACEUTICAL CO., LTD. [JP]/[JP] (AllExceptUS)
  • OGATA, Kazumi [JP]/[JP] (UsOnly)
  • NAKAO, Hidetoshi [JP]/[JP] (UsOnly)
  • ITO, Kazuhiro [JP]/[JP] (UsOnly)
  • SAKAUE, Takahiro [JP]/[JP] (UsOnly)
  • INOUE, Sachiko [JP]/[JP] (UsOnly)
  • IEMURA, Masahito [JP]/[JP] (UsOnly)
Inventors
  • OGATA, Kazumi
  • NAKAO, Hidetoshi
  • ITO, Kazuhiro
  • SAKAUE, Takahiro
  • INOUE, Sachiko
  • IEMURA, Masahito
Priority Data
9/1607430.01.1997JP
9/34302812.12.1997JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) HYDROQUINONE DERIVATIVES
(FR) DERIVES D'HYDROQUINONE
Abstract
(EN)
Hydroquinone derivatives useful as an intraocular pressure decreasing agent, an antihypertensive agent and a free radical scavenger, represented by general formula (I) or (II), or pharmacologically acceptable salts thereof. In formula (I), B1 and B2 may be the same or different and each stands for a group selected from the group consisting of a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkoxy group and a carboxyl group which may be at any position of the benzene ring (but may be at other positions of the benzene ring when W is a nitrogen atom); CH3 is at the position 2 or 3; and Ws may be the same or different and each represents a nitrogen or carbon atom. In formula (II), R1, R2, R3 and R4 may be the same or different and each represents a group selected from a hydrogen atom, a lower alkyl group and a lower alkoxy group; and B1 and B2 are each as previously defined.
(FR)
L'invention concerne des dérivés d'hydroquinone, ou bien des sels pharmacologiquement acceptables de ceux-ci, utiles en tant qu'agent réduisant la tension intraoculaire, en tant qu'agent hypotenseur et en tant que phagocyte de radicaux libres. Ces composés correspondent à la formule générale (I) ou (II). Dans ladite formule (I), B1 et B2 peuvent être identiques ou différents et représentent chacun un groupe choisi parmi un atome d'hydrogène, un atome d'halogène, un groupe hydroxyle, un groupe alcoxy inférieur et un groupe carboxyle qui peut se trouver à n'importe quelle position du cycle benzénique (mais qui peut être à d'autres positions du cycle benzénique lorsque W est un atome d'azote), CH3 se trouve à la position 2 ou 3, et les radicaux W peuvent être identiques ou différents et représentent chacun un atome d'azote ou de carbone. Dans ladite formule (II), R1, R2, R3 et R4 peuvent être identiques ou différents et représentent chacun un groupe choisi parmi un atome d'hydrogène, un groupe alkyle inférieur et un groupe alcoxy inférieur, B1 and B2 correspondant à la définition donnée ci-dessus.
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