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1. (WO1998032854) HUMAN APOPTOSIS-ASSOCIATED PROTEIN; ENCODING DNA IS SIMILAR TO P53 RESPONSE MOUSE GENE EI124
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/032854    International Application No.:    PCT/US1998/001421
Publication Date: 30.07.1998 International Filing Date: 26.01.1998
Chapter 2 Demand Filed:    17.08.1998    
IPC:
A61K 38/00 (2006.01), C07K 14/47 (2006.01)
Applicants: INCYTE PHARMACEUTICALS, INC. [US/US]; 3174 Porter Drive, Palo Alto, CA 94304 (US) (For All Designated States Except US).
HILLMAN, Jennifer, L. [US/US]; (US) (For US Only).
GOLI, Surya, K. [IN/US]; (US) (For US Only)
Inventors: HILLMAN, Jennifer, L.; (US).
GOLI, Surya, K.; (US)
Agent: BILLINGS, Lucy, J.; Incyte Pharmaceuticals, Inc., 3174 Porter Drive, Palo Alto, CA 94304 (US)
Priority Data:
08/790,572 29.01.1997 US
Title (EN) HUMAN APOPTOSIS-ASSOCIATED PROTEIN; ENCODING DNA IS SIMILAR TO P53 RESPONSE MOUSE GENE EI124
(FR) PROTEINE HUMAINE ASSOCIEE A L'APOPTOSE; LE CODAGE DE L'ADN EST SIMILAIRE AU GENE DE SOURIS EI124 A REPONSE P53
Abstract: front page image
(EN)The present invention provides a novel human apoptosis-associated protein (NHAAP) and polynucleotides which identify and encode NHAAP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NHAAP and a method for producing NHAAP. The invention also provides for agonists, antibodies, or antogonists specifically binding NHAAP, and their use, in the prevention and treatment of diseases associated with expression of NHAAP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NHAAP for the treatment of diseases associated with the expression of NHAAP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NHAAP.
(FR)La présente invention concerne une nouvelle protéine humaine associée à l'apoptose (NHAAP) et des polynucléotides identifiant et codant ladite NHAAP. Elle concerne également des vecteurs d'expression et des cellules hôtes obtenus par génie génétique comprenant des séquences nucléotidiques codant la NHAAP, ainsi qu'un procédé de production de la NHAAP. L'invention a aussi pour objet des agonistes, des anticorps, ou des antagonistes se liant spécifiquement à la NHAAP, et leur utilisation pour la prévention et le traitement de maladies associées à l'expression de la NHAAP. L'invention porte, en outre, sur l'utilisation de molécules antisens de polynucléotides codant la NHAAP pour le traitement de maladies associées à l'expression de la NHAAP. Enfin, l'invention concerne des méthodes diagnostiques faisant intervenir ledit polynucléotide, ou des fragments ou le complément de ce polynucléotide, et des anticorps se liant spécifiquement à la NHAAP.
Designated States: AT, AU, BR, CA, CH, CN, DE, DK, ES, FI, GB, IL, JP, KR, MX, NO, NZ, RU, SE, SG, US.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)