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1. (WO1998032733) SULFONYL UREA DERIVATIVES AND THEIR USE IN THE CONTROL OF INTERLEUKIN-1 ACTIVITY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/032733 International Application No.: PCT/IB1997/001603
Publication Date: 30.07.1998 International Filing Date: 29.12.1997
Chapter 2 Demand Filed: 06.04.1998
IPC:
C07C 311/60 (2006.01) ,C07C 317/14 (2006.01) ,C07C 323/67 (2006.01) ,C07D 209/08 (2006.01) ,C07D 307/64 (2006.01) ,C07D 317/18 (2006.01) ,C07D 333/34 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
311
Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
50
Compounds containing any of the groups X being a hetero atom, Y being any atom
52
Y being a hetero atom
54
either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
57
having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
60
having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
317
Sulfones; Sulfoxides
14
having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
323
Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
64
containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
67
containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
04
Indoles; Hydrogenated indoles
08
with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02
not condensed with other rings
34
having two or three double bonds between ring members or between ring members and non-ring members
56
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
64
Sulfur atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
317
Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
08
having the hetero atoms in positions 1 and 3
10
not condensed with other rings
14
with substituted hydrocarbon radicals attached to ring carbon atoms
18
Radicals substituted by singly bound oxygen or sulfur atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
333
Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
02
not condensed with other rings
04
not substituted on the ring sulfur atom
26
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
30
Hetero atoms other than halogen
34
Sulfur atoms
Applicants:
PFIZER INC. [US/US]; 235 East 42nd Street New York, NY 10017, US (AllExceptUS)
DOMBROSKI, Mark, Anthony [US/US]; US (UsOnly)
EGGLER, James, Frederick [US/US]; US (UsOnly)
Inventors:
DOMBROSKI, Mark, Anthony; US
EGGLER, James, Frederick; US
Agent:
SPIEGEL, Allen, J.; Pfizer Inc. 235 East 42nd Street New York, NY 10017, US
Priority Data:
60/036,97929.01.1997US
Title (EN) SULFONYL UREA DERIVATIVES AND THEIR USE IN THE CONTROL OF INTERLEUKIN-1 ACTIVITY
(FR) DERIVES DE SULFONYLUREE ET LEUR APPLICATION EN MATIERE DE REGULATION DE L'ACTIVITE DE L'INTERLEUKINE-1
Abstract:
(EN) A compound of formula (I) wherein R1 and R2 are as defined in the description, R2 being an aromatic group, useful in the treatment and condition selected from the group consisting of the group meningitis and salpingitis, septic shock, disseminated intravascular coagulation, and/or adult respiratory distress syndrome, acute or chronic inflammation, arthritis, cholangitis, colitis, encephalitis, endocarditis, glomerulonephritis, hepatitis, myocarditis, pancreatitis, pericarditis, reperfusion injury, vasculitis, acute and delayed hypersensitivity, graft rejection, and graft-versus-host disease, auto-immune diseases including Type 1 diabetes mellitus and multiple sclerosis, periodonate diseases, interstitial pulmonary fibrosis, cirrhosis, systemic sclerosis, keloid formation tumors which produce IL-1 as an autocrine growth factor, cachexia, Alzeimer's disease, percussion injury, depression, atherosclerosis, osteoporosis in a mammal, including a human.
(FR) L'invention a trait à un composé de la formule (I) dans laquelle R1 et R2 sont tels que définis dans le descriptif. R2 représente un groupe aromatique, des plus utile en matière de traitement de troubles faisant partie de l'ensemble représenté par les méningite et salpingite, le choc septique, la coagulation intravasculaire disséminée et/ou le syndrome de détresse respiratoire de l'adulte, les inflammations aiguës ou chroniques, l'arthrite, l'angiocholite, la colite, l'encéphalite, l'endocardite, la glomérulonéphrite, l'hépatite, la myocardite, la pancréatite, la péricardite, les troubles associés à la reperfusion, les lésions, l'angéite, la réaction immunitaire aiguë ou retardée, le rejet de transplant, la maladie homologue, les affections auto-immunes, notamment le diabète sucré insulino-dépendant et la sclérose en plaques, les paradontolyses, la fibrose interstitielle pulmonaire, la cirrhose, la sclérodermie systémique, les tumeurs de formation de type chéloïde produisant IL-1 comme facteur de croissance autocrine, la cachexie, la maladie d'Alzheimer, la dépression, l'athérosclérose et l'ostéoporose chez le mammifère, race humaine comprise.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CZPV1999-2575IS5099NO19993658SK98299TR1999/01816YUP-337/99
MXPA/a/1999/007030KR1020000070541SG65991VN4111IL130855MA26468
AR011093EP0964849EP1270554EP1270565US6166064JP2000511200
CN1245490CA2279186EA199900603DE000069722663DE000069729762PT964849
PT1270565NZ336248AU1998052340VN4111MYPI 98000291BG103597