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Machine translation
1. (WO1998032444) USE OF FXR, PPAR$g(a) AND LXR$g(a) ACTIVATORS TO RESTORE BARRIER FUNCTION, PROMOTE EPIDERMAL DIFFERENTIATION AND INHIBIT PROLIFERATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/032444    International Application No.:    PCT/US1998/001276
Publication Date: 30.07.1998 International Filing Date: 22.01.1998
Chapter 2 Demand Filed:    28.07.1998    
IPC:
A61K 31/00 (2006.01), A61K 31/045 (2006.01), A61K 31/08 (2006.01), A61K 31/11 (2006.01), A61K 31/192 (2006.01), A61K 31/20 (2006.01), A61K 31/201 (2006.01), A61K 31/202 (2006.01), A61K 31/215 (2006.01), A61K 31/216 (2006.01), A61K 31/22 (2006.01), A61K 31/336 (2006.01), A61K 31/505 (2006.01), A61K 31/56 (2006.01), A61K 31/575 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 22nd floor, 300 Lakeside Drive, Oakland, CA 94612-3550 (US) (For All Designated States Except US).
ELIAS, Peter, M. [US/US]; (US) (For US Only).
BASS, Nathan, M. [US/US]; (US) (For US Only).
HANLEY, Karen [US/US]; (US) (For US Only).
FEINGOLD, Kenneth, R. [US/US]; (US) (For US Only)
Inventors: ELIAS, Peter, M.; (US).
BASS, Nathan, M.; (US).
HANLEY, Karen; (US).
FEINGOLD, Kenneth, R.; (US)
Agent: HEINES, M., Henry; Townsend and Townsend and Crew LLP, 8th floor, Two Embarcadero Center, San Francisco, CA 94111 (US)
Priority Data:
08/788,973 24.01.1997 US
Title (EN) USE OF FXR, PPAR$g(a) AND LXR$g(a) ACTIVATORS TO RESTORE BARRIER FUNCTION, PROMOTE EPIDERMAL DIFFERENTIATION AND INHIBIT PROLIFERATION
(FR) UTILISATION D'ACTIVATEURS DE FXR, PPAR$g(a) ET LXR$g(a) DANS LE BUT DE RESTAURER LA FONCTION DE BARRIERE, DE FAVORISER LA DIFFERENCIATION EPIDERMIQUE ET D'INHIBER LA PROLIFERATION EPIDERMIQUE
Abstract: front page image
(EN)Disorders of the skin and mucous membranes that have a disrupted or dysfunctional epidermal barrier are treated or prevented by topical application of compounds that are either activators of the farnesoid X receptor, activators of the peroxisome proliferator-activated receptor $g(a), and oxysterol activators of the LXR$g(a) receptor. The same compounds are also effective in treating disorders of epidermal differentiation and proliferation.
(FR)La présente invention permet de prévenir ou de traiter les maladies de la peau et des muqueuses qui présentent une rupture ou un dysfonctionnement de la barrière épidermique par l'application locale de composés constitués d'activateurs du récepteur activé par les farnésoïdes X, d'activateurs du récepteur $g(a) activé par un proliférateur de peroxysomes, et d'activateurs oxystérols du récepteur LXR$g(a). Les mêmes composés sont également efficaces dans le traitement des troubles de la différenciation et de la prolifération épidermiques.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)