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1. (WO1998032427) THERAPEUTIC TREATMENT AND PREVENTION OF INFECTIONS WITH A BIOACTIVE MATERIAL ENCAPSULATED WITHIN A BIODEGRADABLE-BIOCOMPATIBLE POLYMERIC MATRIX
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/032427    International Application No.:    PCT/US1998/001556
Publication Date: 30.07.1998 International Filing Date: 27.01.1998
Chapter 2 Demand Filed:    26.08.1998    
IPC:
A61K 38/17 (2006.01), A61K 38/19 (2006.01), A61K 39/00 (2006.01), A61K 39/108 (2006.01), A61K 39/29 (2006.01), A61K 9/16 (2006.01)
Applicants: UNITED STATES GOVERNMENT as represented by THE SECRETARY OF THE ARMY [US/US]; Intellectual Property Law Division, OTJAG, DA, Suite 713, 901 North Stuart Street, Arlington, VA 22203-1837 (US) (For All Designated States Except US).
SETTERSTROM, Jean, A. [US/US]; (US) (For US Only).
VAN HAMONT, John, E. [US/US]; (US) (For US Only).
REID, Robert, H. [US/US]; (US) (For US Only).
JACOB, Elliot [US/US]; (US) (For US Only).
JEYANTHI, Ramasubbu [US/US]; (US) (For US Only).
BOEDEKER, Edgar, C. [US/US]; (US) (For US Only).
MCQUEEN, Charles, E. [US/US]; (US) (For US Only).
TICE, Thomas, R. [US/US]; (US) (For US Only).
ROBERTS, F., Donald [US/US]; (US) (For US Only).
FRIDEN, Phil [US/US]; (US) (For US Only)
Inventors: SETTERSTROM, Jean, A.; (US).
VAN HAMONT, John, E.; (US).
REID, Robert, H.; (US).
JACOB, Elliot; (US).
JEYANTHI, Ramasubbu; (US).
BOEDEKER, Edgar, C.; (US).
MCQUEEN, Charles, E.; (US).
TICE, Thomas, R.; (US).
ROBERTS, F., Donald; (US).
FRIDEN, Phil; (US)
Agent: BELLAMY, Werten, F., W.; Intellectual Property Law Division, Office of The Judge Advocate General, DA, Suite 713, 901 North Stuart Street, Arlington, VA 22203-1837 (US)
Priority Data:
08/789,734 27.01.1997 US
Title (EN) THERAPEUTIC TREATMENT AND PREVENTION OF INFECTIONS WITH A BIOACTIVE MATERIAL ENCAPSULATED WITHIN A BIODEGRADABLE-BIOCOMPATIBLE POLYMERIC MATRIX
(FR) TRAITEMENT THERAPEUTIQUE ET PREVENTION D'INFECTIONS A L'AIDE DE SUBSTANCES BIOACTIVES ENCAPSULEES DANS UNE MATRICE POLYMERE BIODEGRADABLE-BIOCOMPATIBLE
Abstract: front page image
(EN)Novel burst-free, sustained release biocompatible and biodegradable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer, which may contain a pharmaceutically acceptable adjuvant, as a blend of upcapped free carboxyl end group and end-capped forms ranging in ratios from 100/0 to 1/99.
(FR)Cette invention se rapporte à de nouvelles microcapsules biocompatibles et biodégradables à libération prolongée, sans pic, qui peuvent être programmées pour libérer leur noyau actif pour des durées variables allant de 1 à 100 jours dans un milieu physiologique aqueux. Ces microcapsules sont constituées par un noyau de polypeptides ou d'un autre agent biologiquement actif encapsulé dans une matrice de copolymères de poly(lactide/glycolide), qui peut contenir un adjuvant acceptable sur le plan pharmaceutique, se présentant sous la forme d'un mélange de groupes terminaux à carboxyle libre sans coiffe et de formes à coiffe terminale selon des rapports compris entre 100/0 et 1/99.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)