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Machine translation
1. (WO1998032425) PHARMACEUTICAL FORMULATIONS WITH DELAYED DRUG RELEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/032425    International Application No.:    PCT/IB1997/001632
Publication Date: 30.07.1998 International Filing Date: 16.12.1997
Chapter 2 Demand Filed:    23.07.1998    
IPC:
A61K 9/00 (2006.01), A61K 9/28 (2006.01), A61K 9/48 (2006.01)
Applicants: POLI INDUSTRIA CHIMICA S.P.A. [IT/IT]; Piazza Agrippa, 1, I-20141 Milano (IT) (For All Designated States Except US).
BUSETTI, Cesare [IT/IT]; (IT) (For US Only).
CRIMELLA, Tiziano [IT/IT]; (IT) (For US Only)
Inventors: BUSETTI, Cesare; (IT).
CRIMELLA, Tiziano; (IT)
Agent: HORNER, Martin, Grenville; Cruikshank & Fairweather, 19 Royal Exchange Square, Glasgow G1 3AE (GB)
Priority Data:
08/790,514 29.01.1997 US
Title (EN) PHARMACEUTICAL FORMULATIONS WITH DELAYED DRUG RELEASE
(FR) FORMULATIONS PHARMACEUTIQUES A LIBERATION RETARDEE
Abstract: front page image
(EN)The present invention provides methods of treating early morning pathologies using a time-specific controlled release dosage formulation which is administered prior to sleep, and which permits or achieves delivery of a pharmaceutically active agent effective for the treatment of the specific early morning pathology to be treated, at about the time of awakening. The time-specific controlled release dosage formulation comprises $i((1)) a core including the pharmaceutically active agent(s) effective for the treatment of the early morning pathology, and $i((2)) a swellable polymeric coating layer substantially surrounding the core. The swellable polymeric coating layer delays the release of the pharmaceutically active agent from the core for a predetermined period of time dependent upon the thickness of the swellable polymeric coating layer, to effect delivery of the pharmaceutically active agent at about the time of awakening.
(FR)Cette invention a trait à des méthodes de traitement de pathologies matutinales faisant intervenir une forme posologique à libération lente, à partir d'un moment précis, administrée avant le coucher, laquelle forme facilite l'apport d'un agent actif du point de vue pharmaceutique, efficace s'agissant de traiter des pathologies, spécifiques du matin, vers le moment du réveil. Cette forme posologique est constituée, $i((1)), d'un noyau comprenant le ou les agents actifs du point de vue pharmaceutique, efficaces s'agissant du traitement de pathologies matutinales et, $i((2)), d'une couche d'enrobage polymère susceptible de dilatation, entourant quasiment le noyau. Cette couche polymère retarde la libération de l'agent actif du point de vue pharmaceutique contenu dans le noyau et ce, durant un laps de temps prédéterminé qui varie en fonction de l'épaisseur de ladite couche. Ce dispositif permet d'obtenir une libération de l'agent actif du point de vue pharmaceutique vers le moment du réveil.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GM, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)