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1. (WO1998031832) METHOD AND KIT FOR DIAGNOSIS OF AN INCREASED RISK OF CARDIOVASCULAR DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/031832 International Application No.: PCT/NL1998/000029
Publication Date: 23.07.1998 International Filing Date: 19.01.1998
Chapter 2 Demand Filed: 20.08.1998
IPC:
C12Q 1/68 (2006.01)
Applicants: GROBBEE, Diederick, Egbertus[NL/NL]; NL (UsOnly)
KLUFT, Cornelis[NL/NL]; NL (UsOnly)
NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO[NL/NL]; Liebenwalder Str. 8 13055 Berlin, DE (AllExceptUS)
Inventors: GROBBEE, Diederick, Egbertus; NL
KLUFT, Cornelis; NL
Agent: DE BRUIJN, Leendert, C.; Nederlandsch Octrooibureau Scheveningseweg 82 P.O. Box 29720 NL-2502 LS The Hague, NL
Priority Data:
100504720.01.1997NL
Title (EN) METHOD AND KIT FOR DIAGNOSIS OF AN INCREASED RISK OF CARDIOVASCULAR DISEASES
(FR) PROCEDE ET KIT PERMETTANT DE DIAGNOSTIQUER UN RISQUE ACCRU DE MALADIES CARDIO-VASCULAIRES
Abstract:
(EN) The invention relates to a method for indicating groups at risk of cardiovascular diseases. In particular, the invention offers the possibility of determining whether a person, by smoking, has an increased risk of cardiovascular disease on the basis of a genetic predisposition. A polymorphism has now been found which is clearly associated with an increased risk of cardiovascular disease in smokers in contrast to non-smokers. Smokers who possess a specific allele are at appreciably greater risk than smokers who do not possess this allele.
(FR) La présente invention se rapporte à un procédé permettant de repérer des groupes à risque s'agissant de contracter des maladies cardio-vasculaires. L'invention offre notamment la possibilité d'évaluer si une personne, qui fume, présente un risque accru de contracter une maladie cardio-vasculaire, sur la base d'une prédisposition génétique. On a découvert un polymorphisme qui est clairement associé à un risque accru de maladie cardio-vasculaire chez les fumeurs par rapport aux non fumeurs. Les fumeurs qui possèdent un allèle spécifique présentent un risque sensiblement supérieur que les fumeurs qui ne possèdent pas cet allèle.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)