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1. (WO1998031669) NOVEL ARYLPIPERAZINE DERIVED FROM PIPERIDINE AS ANTIDEPRESSANT MEDICINES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/031669    International Application No.:    PCT/FR1998/000068
Publication Date: 23.07.1998 International Filing Date: 15.01.1998
Chapter 2 Demand Filed:    10.08.1998    
IPC:
C07D 211/16 (2006.01), C07D 211/32 (2006.01), C07D 211/52 (2006.01), C07D 211/64 (2006.01)
Applicants: PIERRE FABRE MEDICAMENT [FR/FR]; 45, place Abel Gance, F-92100 Boulogne-Billancourt (FR) (For All Designated States Except US).
HALAZY, Serge [BE/FR]; (FR) (For US Only).
LAMOTHE, Marie [FR/FR]; (FR) (For US Only).
JORAND-LEBRUN, Catherine [FR/FR]; (FR) (For US Only)
Inventors: HALAZY, Serge; (FR).
LAMOTHE, Marie; (FR).
JORAND-LEBRUN, Catherine; (FR)
Agent: MARTIN, Jean-Jacques; Cabinet Regimbeau, 26, avenue Kléber, F-75116 Paris (FR)
Priority Data:
97/00336 15.01.1997 FR
Title (EN) NOVEL ARYLPIPERAZINE DERIVED FROM PIPERIDINE AS ANTIDEPRESSANT MEDICINES
(FR) NOUVELLES ARYLPIPERAZINES DERIVEES DE PIPERIDINE COMME MEDICAMENTS ANTIDEPRESSEURS
Abstract: front page image
(EN)The invention concerns compounds of formula (I) in which in particular, R1 represents R'1, OR'1, SR'1, NHR'1, COR'1, CHOHR'1, CH2R'1, in which R'1 represents an aryl radical selected among a phenyl, a naphthyl or a pyridyl; R2 represents a halogen (Cl, F, Br), OH, NH2, CN, NO2, R'2, OR'2, SR'2, NHR'2, COR'2, CHOHR'2, COOR'2, NHCOR'2, NHCOOR'2, NHSO2R'2, OCONHR'2, in which R'2 represents an alkyl chain linear or branched, an aryl or an arylalkyl; Z represents CO-(CH2)n-O, CO-(CH2)n-NH, (CH2)m-O,(CH2)m-NH, CO-(CH2)p-CONH-, (CH2)p-CONH, CO-(CH2)p-NHCONH-, (CH2)m-NHCONH, -CO(CH2)p-OCONH-, (CH2)m-OCONH, -CO(CH2)p-NHCOO, (CH2)m-NHCOO, in which n represents zero or a whole number ranging between 1 and 8, m represents a whole number ranging between 2 and 8 and p represents a whole number ranging between 1 and 8; Ar represents an aromatic radical such as a phenyl or a naphthyl; R3 represents an alkyl radical linear or branched containing 1 to 6 carbon atoms: These compounds are particularly useful as antidepressant drugs.
(FR)La présente invention concerne les composés de formule (I) dans laquelle notamment, R1 représente R'1, OR'1, SR'1, NHR'1, COR'1, CHOHR'1, CH2R'1, dans lesquels R'1 represente un reste aryle choisi parmi un phényle, un naphtyle ou un pyridyle; R2 représente un halogène (Cl, F, Br), OH, NH2, CN, NO2, R'2, OR'2, SR'2, NHR'2, COR'2, CHOHR'2, COOR'2, NHCOR'2, NHCOOR'2, NHSO2R'2, OCONHR'2, dans lesquels R'2 représente une chaîne alkyle linéaire ou ramifiée, un aryle ou un alkylaryle; Z représente CO-(CH2)n-O, CO-(CH2)n-NH, (CH2)m-O, (CH2)m-NH, CO-(CH2)p-CONH-, (CH2)p-CONH, CO-(CH2)p-NHCONH-, (CH2)m-NHCONH, -CO(CH2)p-OCONH-, (CH2)m-OCONH, -CO(CH2)p-NHCOO-, (CH2)m-NHCOO, dans lesquels n représente zéro ou un nombre entier compris entre 1 et 8, m représente un nombre entier compris entre 2 et 8 et p représente un nombre entier compris entre 1 et 8; Ar représente un radical aromatique tel qu'un phényle ou un naphtyle; R3 représente un radical alkyle linéaire ou ramifié comprenant de 1 à 6 atomes de carbone. Ces composés sont notamment utiles comme médicaments antidépresseurs.
Designated States: AU, BR, CA, CN, JP, KR, MX, NZ, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: French (FR)
Filing Language: French (FR)