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1. (WO1998031664) BIS-SULFONOMIDES HYDROXAMIC ACIDS AS MMP INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/031664    International Application No.:    PCT/US1998/000983
Publication Date: 23.07.1998 International Filing Date: 09.01.1998
Chapter 2 Demand Filed:    16.07.1998    
IPC:
C07C 311/19 (2006.01), C07C 311/29 (2006.01)
Applicants: PHARMACIA & UPJOHN COMPANY [US/US]; 301 Henrietta Street Kalamazoo, MI 49001 (US) (For All Designated States Except US).
JACOBSEN, Eric, Jon [US/US]; (US) (For US Only).
SKALETZKY, Louis, L. [US/US]; (US) (For US Only)
Inventors: JACOBSEN, Eric, Jon; (US).
SKALETZKY, Louis, L.; (US)
Agent: YANG, Lucy, X.; Pharmacia & Upjohn Company Intellectual Property Legal Services 301 Henrietta Street Kalamazoo, MI 49001 (US).
MAZZINI, Giuseppe; Pharmacia & Upjohn SpA Viale Pasteur, 10 I-20014 Nerviano (IT)
Priority Data:
60/037,625 17.01.1997 US
Title (EN) BIS-SULFONOMIDES HYDROXAMIC ACIDS AS MMP INHIBITORS
(FR) ACIDES HYDROXAMIQUES BIS-SULFAMIDES COMME INHIBITEURS DE METALLOPROTEINASES MATRICIELLES
Abstract: front page image
(EN)The present invention provides a compound of formula (I) or pharmaceutically acceptable salts thereof wherein R1 and R2 are the same or different and are C1-10alkyl, phenyl, hetero-aryl, or phenyl substituted with C1-4alkyl, OR3, NHR3, CONHR3, NHCOR3, or halo; wherein R3 is H, or C1-4alkyl; and n is 1, 2, 3, 4, 5 or 6. The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation.
(FR)La présente invention concerne un composé de la formule (I) ou des sels de ce composé acceptables du point de vue pharmaceutique; dans la formule (I) de l'invention, R1 et R2 sont identiques ou différents et représentent un alkyle en C1-10, un phényle, un hétéro-aryle, ou un phényle substitué par un alkyle en C1-4, OR3, NHR3, CONHR3, NHCOR3, ou un halo; R3 représente H, ou un alkyle en C1-4; et n représente 1, 2, 3, 4, 5, ou 6. Les composés sont des inhibiteurs de métalloprotéinases matricielles impliquées dans la dégradation de tissus.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)