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1. (WO1998031383) MODIFIED TUMOR NECROSIS FACTOR
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/031383 International Application No.: PCT/US1998/000683
Publication Date: 23.07.1998 International Filing Date: 15.01.1998
Chapter 2 Demand Filed: 11.08.1998
IPC:
A61K 38/00 (2006.01) ,C07K 14/525 (2006.01)
Applicants: PHOENIX PHARMACOLOGICS, INC.[US/US]; 115 John Robert Thomas Drive Exton, PA 19341, US
Inventors: CLARK, Mike, A.; US
Agent: ELDERKIN, Dianne, B. ; Woodcock Washburn Kurtz Mackiewicz & Norris LLP 46th floor One Liberty Place Philadelphia, PA 19103, US
Priority Data:
09/006,81014.01.1998US
60/035,52115.01.1997US
Title (EN) MODIFIED TUMOR NECROSIS FACTOR
(FR) FACTEUR DE NECROSE DES TUMEURS MODIFIE
Abstract:
(EN) Modifying TNF with polyethyleneglycol (PEG) having an approximate weight average molecular weight in the range of about 10,000 to about 40,000, preferably in the range of about 20,000 to 30,000, significantly increases the circulating half-life of the TNF. As a result, lower doses of the TNF may be administered to effectively treat tumors, with fewer, accompanying adverse side effects to the patient.
(FR) La modification de TNF par un polyéthylèneglycol (PEG) présentant un poids moléculaire moyen approximatif compris entre environ 20 000 et environ 40 000, et de préférence dans une fourchette d'environ 20 000 à 30 000, accroît de manière significative la demi-vie circulante du TNF. Des doses plus faibles de TNF peuvent par conséquent être administrées pour traiter efficacement les tumeurs avec moins d'effets secondaires indésirables pour le patient.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)