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1. WO1998030712 - A PROCESS FOR THE PRODUCTION OF CRYSTALLINE ASPARTIC ACID

Publication Number WO/1998/030712
Publication Date 16.07.1998
International Application No. PCT/US1998/000290
International Filing Date 08.01.1998
Chapter 2 Demand Filed 31.07.1998
IPC
C08G 69/10 2006.01
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
69Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
02Polyamides derived from amino carboxylic acids or from polyamines and polycarboxylic acids
08derived from amino carboxylic acids
10Alpha-amino-carboxylic acids
C08G 73/10 2006.01
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
73Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen, with or without oxygen or carbon, not provided for in groups C08G12/-C08G71/238
06Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule; Polyhydrazides; Polyamide acids or similar polyimide precursors
10Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
C12P 7/46 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
40containing a carboxyl group
44Polycarboxylic acids
46Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
C12P 13/20 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
13Preparation of nitrogen-containing organic compounds
04Alpha- or beta-amino acids
20Aspartic acid; Asparagine
CPC
C08G 69/10
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
69Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
02Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
08derived from amino-carboxylic acids
10Alpha-amino-carboxylic acids
C08G 73/1092
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
73Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
06Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
10Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
1092Polysuccinimides
C12P 13/20
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
13Preparation of nitrogen-containing organic compounds
04Alpha- or beta- amino acids
20Aspartic acid; Asparagine
C12P 7/46
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
40containing a carboxyl group ; including Peroxycarboxylic acids
44Polycarboxylic acids
46Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
Applicants
  • AMYLUM BELGIUM N.V. [BE]/[BE] (UsOnly)
  • A.E. STALEY MANUFACTURING CO. [US]/[US] (UsOnly)
  • EYAL, Aharon, Meir [IL]/[IL] (UsOnly)
  • VITNER, Asher [IL]/[IL] (UsOnly)
  • CAMI, Pierre [FR]/[FR] (UsOnly)
  • JANSEN, Robert [US]/[BE] (UsOnly)
  • JARRY, Bruno [FR]/[FR] (UsOnly)
  • LECOMTE, Didier [FR]/[FR] (UsOnly)
  • SCOTT, Jean [FR]/[FR] (UsOnly)
  • CHATTAWAY, Thomas [FR]/[BE] (UsOnly)
  • VAN LANCKER, Frank [BE]/[BE] (UsOnly)
Inventors
  • EYAL, Aharon, Meir
  • VITNER, Asher
  • CAMI, Pierre
  • JANSEN, Robert
  • JARRY, Bruno
  • LECOMTE, Didier
  • SCOTT, Jean
  • CHATTAWAY, Thomas
  • VAN LANCKER, Frank
Agents
  • SAXE, Bernhard, D.
Priority Data
11998609.01.1997IL
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) A PROCESS FOR THE PRODUCTION OF CRYSTALLINE ASPARTIC ACID
(FR) PROCEDE POUR PRODUIRE DE L'ACIDE ASPARTIQUE CRISTALLIN
Abstract
(EN)
The invention provides process for the production of aspartic acid comprising the steps of: (a) forming an aqueous solution containing diammonium fumarate, using per mole of diammonium fumarate about two moles of an ammonia source, a part of which is recycled from a step of the present process; (b) adjusting the composition of an aqueous solution containing diammonium fumarate obtained through a step of the present process to form a solution having a concentration of about 0.5M to about 2M ammonium fumarate and having a pH of about between 7 and 9; (c) enzymatically converting diammonium fumarate in the adjusted aqueous solution into monoammonium aspartate; (d) acidulating a solution containing the monoammonium aspartate by contacting with a cation exchanger which is at least partially in its acid form, at an elevated temperature of at least 50 °C, whereby ammonium ions are transferred from the solution to the cation exchanger and protons are transferred from the cation exchanger to the solution thereby forming aspartic acid therein; (e) separating the aspartic acid containing aqueous solution from the ammonium ion-carrying cation exchanger; (f) separating the aspartic acid from the aqueous solution formed in step (e) by methods known per se; (g) regenerating the ammonium ion-carrying cation exchanger back to a cation exchanger which is at least partially in its acid form in a method that forms an ammonia source; (h) separating and reusing the converted cation exchanger in step (d); and (i) separating and reusing the ammonia source in step (a).
(FR)
Un procédé permettant de produire de l'acide aspartique comprend les étapes suivantes: (a) on forme une solution aqueuse contenant du fumarate dibasique d'ammonium en utilisant par mole de fumarate environ deux moles d'une source d'ammoniaque, dont une partie est recyclée à partir d'une étape du présent procédé; (b) on ajuste la composition d'une solution aqueuse contenant le fumarate dibasique d'ammonium obtenu par une étape du présent procédé, de façon à former une solution ayant une concentration comprise entre 0,5 et 2 M environ de fumarate d'ammonium et un pH compris entre 7 et 9 environ; (c) on convertit par une action enzymatique le fumarate dibasique d'ammonium, dans la solution aqueuse ajustée, en aspartate monobasique d'ammonium; (d) on acidifie une solution contenant l'aspartate monobasique d'ammonium en la mettant en contact avec un échangeur de cations, qui se trouve au moins partiellement sous sa forme acide, à une température élevée d'au moins 50 °C, les ions ammonium étant transférés de la solution à l'échangeur de cations et les protons étant transférés de l'échangeur de cations à la solution, ce qui forme dans celle-ci de l'acide aspartique; (e) on sépare la solution aqueuse contenant l'acide aspartique de l'échangeur de cations portant les ions ammonium; (f) on sépare l'acide aspartique de la solution aqueuse formée à l'étape (e) par des procédés connus en soi; (g) on régénère l'échangeur de cations portant les ions ammonium, de façon à obtenir un échangeur de cations qui se trouve au moins partiellement sous sa forme acide, selon un procédé qui forme une source d'ammoniaque; (h) on sépare et on réutilise l'échangeur de cations converti à l'étape (d); et (i) on sépare et on réutilise la source d'ammoniaque à l'étape (a).
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