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Machine translation
1. (WO1998030576) NOVEL HEDGEHOG-DERIVED POLYPEPTIDES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/030576    International Application No.:    PCT/US1997/015753
Publication Date: 16.07.1998 International Filing Date: 07.10.1997
Chapter 2 Demand Filed:    05.05.1998    
IPC:
A61K 38/00 (2006.01), C07K 14/435 (2006.01), C07K 14/46 (2006.01), C07K 14/47 (2006.01), G01N 33/50 (2006.01), G01N 33/68 (2006.01)
Applicants: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE [US/US]; 720 Rutland Avenue, Baltimore, MD 21205 (US) (For All Designated States Except US).
BEACHY, Philip, A. [US/US]; (US) (For US Only).
PORTER, Jeffrey, A. [US/US]; (US) (For US Only)
Inventors: BEACHY, Philip, A.; (US).
PORTER, Jeffrey, A.; (US)
Agent: HAILE, Lisa, A.; Fish & Richardson P.C., Suite 1400, 4225 Executive Square, La Jolla, CA 92037 (US)
Priority Data:
08/729,743 07.10.1996 US
60/061,323 02.10.1997 US
Title (EN) NOVEL HEDGEHOG-DERIVED POLYPEPTIDES
(FR) NOUVEAUX POLYPEPTIDES DERIVES D'UNE PROTEINE HERISSON
Abstract: front page image
(EN)The present invention provides two novel polypeptides, referred to as the 'N' and 'C' fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G$m(9)CF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described.
(FR)L'invention concerne deux nouveaux polypeptides, désignés par les termes de fragments hérissons N et C, ou de fragments N-terminal ou C-terminal, respectivement, qui sont obtenus par clivage spécifique au niveau du site G$m(9)CF reconnu par le domaine auto-protéolytique de la protéine native. L'invention concerne également des polypeptides hérissons modifiés par un stérol, ainsi que leurs fragments fonctionnels. Elle concerne enfin des méthodes permettant d'identifier des compositions qui modifient l'activité hérisson en inhibant la modification par le cholestérol de la protéine hérisson.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, ZW.
African Regional Intellectual Property Organization (GH, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)