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1. (WO1998030563) 2-HYDROXYMETHYLCYCLOPROPYLI- DENEMETHYLPURINES AND -PYRIMIDINES AS ANTIVIRAL AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/030563 International Application No.: PCT/US1998/000440
Publication Date: 16.07.1998 International Filing Date: 07.01.1998
Chapter 2 Demand Filed: 18.06.1998
IPC:
C07D 239/46 (2006.01) ,C07D 239/54 (2006.01) ,C07D 473/00 (2006.01) ,C07F 9/6506 (2006.01) ,C07F 9/6561 (2006.01)
Applicants: ZEMLICKA, Jiri[US/US]; US (UsOnly)
QIU, Yao-Ling[CN/US]; US (UsOnly)
DRACH, John, C.[US/US]; US (UsOnly)
PTAK, Roger, G.[US/US]; US (UsOnly)
THE REGENTS OF THE UNIVERSITY OF MICHIGAN[US/US]; Technology Management Office Wolverine Tower, Room 2071 3003 S. State Street Ann Arbor, MI 48109-1280, US (UsOnly)
WAYNE STATE UNIVERSITY[US/US]; 4032 Faculty Administration Building 656 West Kirby Detroit, MI 48202, US (UsOnly)
Inventors: ZEMLICKA, Jiri; US
QIU, Yao-Ling; US
DRACH, John, C.; US
PTAK, Roger, G.; US
Agent: SMITH, DeAnn, F. ; Lahive & Cockfield, LLP 28 State Street Boston, MA 02109, US
Priority Data:
60/035,82608.01.1997US
60/045,67606.05.1997US
Title (EN) 2-HYDROXYMETHYLCYCLOPROPYLI- DENEMETHYLPURINES AND -PYRIMIDINES AS ANTIVIRAL AGENTS
(FR) 2-HYDROXYMETHYLECYCLOPROPYLI- DENEMETHYLPURINES ET -PYRIMIDINES UTILISES COMME AGENTS ANTIVIRAUX
Abstract: front page image
(EN) Compounds which are active against viruses have Formulas (I), (II), (III) and (IV), wherein B is a purine or pyrimidine heterocyclic ring and is preferably selected from the group consisting of 6-aminopurine (adenine), 2,6-diaminopurine, 2-amino-6-cyclopropylaminopurine, 6-hydroxypurine (hypoxanthine), 2-amino-6-halo substituted purines, 2-amino-6-alkoxy substituted purines, 2-amino-6-hydroxypurine (guanine), 3-deazapurines, 7-deazapurines, 8-azapurines, cytosine, 5-halo substituted cytosines, 5-alkyl substituted cytosines, thymine, uracil and 6-azapyrimidines; X is O; and R1 and R2 are alkyl or aryl groups. The R1X and/or R2X can also be amino acid residues with X as NH.
(FR) L'invention concerne des composés ayant une activité antivirale et répondant aux formules (I), (II), (III) et (IV) dans lesquelles B est un noyau hétérocyclique de purine ou de pyrimidine, sélectionné de préférence dans le groupe qui comprend 6-aminopurine (adénine), 2,6-diaminopurine, 2-amino-6-cyclopropylaminopurine, 6-hydroxypurine (hypoxanthine), purines à substitution 2-amino-6-halo, purines à substitution 2-amino-6-alcoxy, 2-amino-6-hydroxypurine (guanine), 3-déazapurines, 7-déazapurines, 8-azapurines, cytosine, cytosines à substitution 5-halo, cytosines à substitution 5-alkyle, thymine, uracile; dans lesquelles X est O, R1 et R2 étant des groupes alkyle ou aryle. R1X et/ou R2X peuvent également être des restes d'acides aminés avec X représentant NH.
Designated States: CA, JP, US
European Patent Office (EPO) (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)