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1. (WO1998030551) MACROCYCLIC INHIBITORS OF MATRIX METALLOPROTEINASES AND TNF$g(a) SECRETION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/030551    International Application No.:    PCT/US1998/000144
Publication Date: 16.07.1998 International Filing Date: 07.01.1998
Chapter 2 Demand Filed:    15.07.1998    
IPC:
C07D 225/06 (2006.01), C07D 245/02 (2006.01), C07D 245/06 (2006.01), C07D 267/00 (2006.01), C07D 413/04 (2006.01), C07D 413/06 (2006.01), C07D 417/06 (2006.01), C07D 487/08 (2006.01), C07K 5/078 (2006.01)
Applicants: ABBOTT LABORATORIES [US/US]; CHAD 0377/AP6D-2, 100 Abbott Park Road, Abbott Park, IL 60064-3500 (US)
Inventors: DAVIDSEN, Steven, K.; (US).
STEINMAN, Douglas, H.; (US).
SHEPPARD, George, S.; (US).
XU, Lianhong; (US).
HOLMS, James, H.; (US).
GUO, Yan; (US).
FLORJANCIC, Alan, Scott; (US).
SIUMMERS, James, B.; (US).
MICHAELIDES, Michael, R.; (US)
Agent: STEELE, Gregory, W.; Abbott Laboratories, CHAD 0377/AP6D-2, 100 Abbott Park Road, Abbott Park, IL 60064-3500 (US)
Priority Data:
08/782,061 07.01.1997 US
Title (EN) MACROCYCLIC INHIBITORS OF MATRIX METALLOPROTEINASES AND TNF$g(a) SECRETION
(FR) INHIBITEURS MACROCYCLIQUES DE METALLOPROTEINASES MATRICIELLES ET DE SECRETION DE FNT$g(a)
Abstract: front page image
(EN)Macrocyclic compounds of formula (I) are potent inhibitors of matrix metalloproteinase and are useful in the treatment of diseases in which matrix metalloproteinase play a role. Also disclosed are matrix metalloproteinase inhibiting compositions and a method of inhibiting matrix metalloproteinase in a mammal.
(FR)Cette invention concerne des composés macrocycliques qui correspondent à la formule (I). Ces composés consistent en de puissants inhibiteurs de métalloprotéinase matricielle, et peuvent être utilisés dans le traitement de maladies où la métalloprotéinase matricielle joue un rôle. Cette invention concerne également des compositions inhibant la métalloprotéinase matricielle, ainsi qu'un procédé d'inhibition de métalloprotéinase matricielle chez un mammifère.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)