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Machine translation
1. (WO1998030543) ENDOTHELIN INTERMEDIATES BY ASYMMETRIC CONJUGATE ADDITION REACTION USING A CHIRAL ADDITIVE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/030543 International Application No.: PCT/US1998/000263
Publication Date: 16.07.1998 International Filing Date: 09.01.1998
Chapter 2 Demand Filed: 20.07.1998
IPC:
C07B 53/00 (2006.01) ,C07D 213/30 (2006.01) ,C07D 213/48 (2006.01) ,C07D 213/55 (2006.01) ,C07D 213/85 (2006.01) ,C07D 263/52 (2006.01)
Applicants: TILLYER, Richard, D.[GB/US]; US (UsOnly)
XU, Feng[CN/US]; US (UsOnly)
TSCHAEN, David, M.[US/US]; US (UsOnly)
MERCK & CO., INC.[US/US]; 126 East Lincoln Avenue Rahway, NJ 07065, US (AllExceptUS)
Inventors: TILLYER, Richard, D.; US
XU, Feng; US
TSCHAEN, David, M.; US
Agent: MERCK & CO., INC.; 126 East Lincoln Avenue Rahway, NJ 07065, US
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue Rahway, NJ 07065, US
Priority Data:
60/035,46214.01.1997US
9705858.021.03.1997GB
Title (EN) ENDOTHELIN INTERMEDIATES BY ASYMMETRIC CONJUGATE ADDITION REACTION USING A CHIRAL ADDITIVE
(FR) INTERMEDIAIRES DE L'ENDOTHELINE OBTENUS PAR REACTION D'ADDITION D'UN CONJUGUE ASYMETRIQUE EFFECTUEE AU MOYEN D'UN ADDITIF CHIRAL
Abstract: front page image
(EN) This invention relates to a process for the preparation of a key intermediate in the synthesis of an endothelin antagonist, having formula (I) by using a chiral additive to effect an asymmetric conjugate addition.
(FR) L'invention concerne un procédé destiné à un processus de préparation d'un intermédiaire clé, dans la synthèse d'un antagoniste de l'endothéline, cet intermédiaire correspondant à la formule (I) et consistant à utiliser un additif chiral pour induire une addition de conjugué àsymétrique.
Designated States: AL, AM, AU, AZ, BA, BB, BG, BR, BY, CA, CN, CU, CZ, EE, GE, GW, HU, ID, IL, IS, JP, KG, KR, KZ, LC, LK, LR, LT, LV, MD, MG, MK, MN, MX, NO, NZ, PL, RO, RU, SG, SI, SK, SL, TJ, TM, TR, TT, UA, US, UZ, VN, YU
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)