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1. (WO1998029432) MYCOBACTERIUM FOL A GENE THAT ENCODES FOR THE ENZYME DIHYDROFOLATE REDUCTASE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/029432 International Application No.: PCT/US1997/023557
Publication Date: 09.07.1998 International Filing Date: 19.12.1997
Chapter 2 Demand Filed: 29.07.1998
IPC:
C07K 14/35 (2006.01) ,C12N 9/06 (2006.01) ,C12Q 1/04 (2006.01) ,C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
35
from Mycobacteriaceae (F)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
02
Oxidoreductases (1.), e.g. luciferase
06
acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
02
involving viable micro-organisms
04
Determining presence or kind of micro-organism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants: SOUTHERN RESEARCH INSTITUTE[US/US]; 2000 North Avenue, South Birmingham, AL 35205, US
Inventors: BARROW, William, W.; US
VAN GINKEL, Sabrina, Z.; US
DOOLEY, Thomas, P.; US
SULING, William, J.; US
Agent: REMENICK, James ; Baker & Botts, L.L.P. The Warner 1299 Pennsylvania Avenue, N.W. Washington, DC 20004, US
Priority Data:
08/990,79115.12.1997US
60/034,72503.01.1997US
60/039,73714.02.1997US
Title (EN) MYCOBACTERIUM FOL A GENE THAT ENCODES FOR THE ENZYME DIHYDROFOLATE REDUCTASE
(FR) GENE $i(FOL) A DE MYCOBACTERIES CODANT L'ENZYME DIHYDROFOLATE REDUCTASE
Abstract:
(EN) The invention relates to the nucleic acid sequence and amino acid sequence of dihydrofolate reductase (DHFR) from mycobacteria and to expression of recombinant DHFR protein. Utilizing the recombinant protein, novel therapies and diagnostic strategies can be developed and selective antimycobacterial compositions can be designed and utilized to treat mycobacterial infections in patients. This invention includes all or portions of novel recombinant nucleic acids encoding DHFR for mycobacteria such as $i(M. avium), to novel recombinant DHFR peptides produced by such sequences, and to vaccines, diagnostic kits, cells and therapies utilizing these peptides and nucleic acid sequences. The present invention relates to methods for using the sequences of the present invention to develop drugs specific to $i(M. avium) and other mycobacteria, to identify and sequence corresponding sequences in species other than $i(M. avium), as well as diagnostic and treatment methods incorporating the disclosed sequences and peptides.
(FR) Cette invention se rapporte à la séquence d'acides nucléiques et à la séquence d'acides aminés de la dihydrofolate réductase (DHFR) provenant de mycobactéries, ainsi qu'à l'expression de la protéine DHFR de recombinaison. Grâce à l'utilisation de cette protéine de recombinaison, il est possible de développer de nouvelles thérapies et de nouvelles stratégies diagnostiques, de concevoir des compositions sélectives antimycobactériennes et de les utiliser pour soigner des patients atteints d'infections mycobactériennes. Cette invention concerne la totalité ou des parties de nouveaux acides nucléiques de recombinaison codant la protéine DHFR de mycobactéries telles que $i(M. avium), à de nouveaux peptides recombinés de DHFR produits par de telles séquences, ainsi qu'à des vaccins, trousses de diagnostic, cellules et thérapies utilisant ces peptides et séquences d'acides nucléiques. La présente invention se rapporte à des procédés d'utilisation desdites séquences pour fabriquer des médicaments spécifiques de $i(M. avium) et d'autres mycobactéries, pour identifier et séquencer des séquences correspondantes dans des espèces autres que $i(M. avium), ainsi qu'à des procédés de diagnostic et de traitement utilisant les séquences et peptides décrits ci-dessus.
Designated States: AU, CA, JP
European Patent Office (EPO) (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)