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1. (WO1998029407) N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/029407    International Application No.:    PCT/US1997/020591
Publication Date: 09.07.1998 International Filing Date: 13.11.1997
Chapter 2 Demand Filed:    10.07.1998    
IPC:
C07D 213/77 (2006.01), C07D 263/14 (2006.01), C07D 401/12 (2006.01), C07D 401/14 (2006.01)
Applicants: HOECHST MARION ROUSSEL, INC. [US/US]; 2110 East Galbraith Road, P.O. Box 156300, Cincinnati, OH 45215-6300 (US)
Inventors: KURYS, Barbara, E.; (US).
FINK, David, M.; (US).
FREED, Brian, S.; (US).
MERRIMAN, Gregory, H.; (US)
Agent: LENTZ, Nelsen, L.; Hoechst Marion Roussel, Inc., 2110 East Galbraith Road, P.O. Box 156300, Cincinnati, OH 45215-6300 (US)
Priority Data:
08/774,308 27.12.1996 US
08/959,789 29.10.1997 US
Title (EN) N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION
(FR) N-(PYRIDINYLAMINO)ISOINDOLINES ET COMPOSES ASSOCIES
Abstract: front page image
(EN)Novel N-(pyridinylamino)isoindolines of formula (I) and related compounds, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the N-(pyridinylamino)isoindolines and related compounds, the intermediates or compositions thereof are disclosed. Formula (I) R is hydrogen, a group of the formula R2O- wherein R2 is hydrogen, loweralkyl, benzyl, a group of the formula (R3)3Si- wherein R3 is loweralkyl, or a group of the formula R4R5NCO- wherein R4 and R5 are independently hydrogen, loweralkyl or benzyl; R4 and R5 taken together with the nitrogen atom to which they are attached form a group of formula (a) or a group of the formula (b); R1 is hydrogen or loweralkyl; X is hydrogen, loweralkyl, halogen, hydroxy loweralkoxy, or trifluoromethyl; Y is hydrogen, loweralkyl, halogen, hydroxy, loweralkoxy, or trifuoromethyl; m is 1 or 2; n is 1, 2, or 3; p is 1 or 2; the optical isomers thereof; or the pharmaceutically acceptable salts thereof.
(FR)L'invention porte sur de nouvelles N-(pyridinylamino)isoindolines et des composés associés, sur des intermédiaires, sur leurs procédés de préparation et sur des méthodes recourant aux N-(pyridinylamino)isoindolines pour atténuer les dysfonctionnements de la mémoire et traiter les dépressions, ainsi que sur des composés associés, leurs intermédiaires ou leurs compositions.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)