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1. (WO1998029116) N-LINKED SULFONAMIDES OF HETEROCYCLIC THIOESTERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/029116    International Application No.:    PCT/US1997/023526
Publication Date: 09.07.1998 International Filing Date: 22.12.1997
Chapter 2 Demand Filed:    30.07.1998    
IPC:
C07D 207/48 (2006.01), C07D 211/96 (2006.01)
Applicants: GUILFORD PHARMACEUTICALS INC. [US/US]; 6611 Tributary Street, Baltimore, MD 21224 (US)
Inventors: HAMILTON, Gregory, S.; (US).
LI, Jia-He; (US).
HUANG, Wei; (US)
Agent: NATH, Gary, M.; Nath & Associates, 6th Floor, 1030 15th Street, N.W., Washington, DC 20005 (US)
Priority Data:
08/775,584 31.12.1996 US
  22.12.1997 US
Title (EN) N-LINKED SULFONAMIDES OF HETEROCYCLIC THIOESTERS
(FR) SULFONAMIDES A LIAISON N DE THIOESTERS HETEROCYCLIQUES
Abstract: front page image
(EN)This invention relates to neurotrophic low molecular weight, small molecule N-linked sulfonamides of heterocyclic thioesters having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
(FR)Cette invention se rapporte à de petites molécules de sulfonamides à liaison N, de faible poids moléculaire, neurotrophiques, de thioesters hétérocycliques, qui possèdent une affinité pour les immunophillines de type FKBP, ainsi qu'à leur utilisation en tant qu'inhibiteurs de l'activité enzymatique associée aux protéines immunophilines, notamment de l'activité enzymatique de type peptidyle-prolyle isomérase ou rotamase.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)