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1. (WO1998028281) FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PROTEIN TYROSINE KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/028281    International Application No.:    PCT/GB1997/003509
Publication Date: 02.07.1998 International Filing Date: 22.12.1997
Chapter 2 Demand Filed:    20.05.1998    
IPC:
C07D 239/70 (2006.01), C07D 401/12 (2006.01), C07D 471/04 (2006.01), C07D 495/04 (2006.01)
Applicants: CELLTECH THERAPEUTICS LIMITED [GB/GB]; 216 Bath Road, Slough, Berkshire SL1 4EN (GB) (For All Designated States Except US).
DAVIS, Jeremy, Martin [GB/GB]; (GB) (For US Only).
DAVIS, Peter, David [GB/GB]; (GB) (For US Only).
MOFFAT, David, Festus, Charles [GB/GB]; (GB) (For US Only).
BATCHELOR, Mark, James [GB/GB]; (GB) (For US Only)
Inventors: DAVIS, Jeremy, Martin; (GB).
DAVIS, Peter, David; (GB).
MOFFAT, David, Festus, Charles; (GB).
BATCHELOR, Mark, James; (GB)
Agent: HALLYBONE, Huw, George; Carpmaels & Ransford, 43 Bloomsbury Square, London WC1A 2RA (GB)
Priority Data:
9626742.2 23.12.1996 GB
9708115.2 22.04.1997 GB
Title (EN) FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PROTEIN TYROSINE KINASE INHIBITORS
(FR) DERIVES POLYCYCLIQUE FONDUS DE 2-AMINOPYRIMIDINE, LEUR PREPARATION ET LEUR UTILISATION COMME INHIBITEURS DE PROTEINE TYROSINE-KINASE
Abstract: front page image
(EN)Fused polycyclic 2-aminopyrimidines of formula (1) wherein Ar is an optionally substituted aromatic or heteroaromatic group; X is a carbon or nitrogen atom; Y is a carbon or nitrogen atom; Z is a linker group; A together with X and Y forms an optionally substituted monocyclic or bicyclic aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof are described. The compounds are potent and selective inhibitors of the protein tyrosine kinases p56lck and p59fyn and are of use in the prophylaxis and treatment of immune diseases, hyperproliferative disorders and other diseases in which inappropriate p56lck and/or p59fyn activity is believed to have a role.
(FR)L'invention concerne des 2-aminopyrimidine polycycliques fondus, ainsi que leurs sels, solvates, hydrates et N-oxydes, et représentés par la formule (1), dans laquelle Ar est un groupe aromatique ou hétéro-aromatique éventuellement substitué; X est atome de carbone ou d'azote; Y est atome de carbone ou d'azote; Z est un groupe lieur; A, X et Y forment un groupe aromatique ou hétéro-aromatique, monocyclique ou bicyclique, éventuellement substitué. Ces composés, qui sont des inhibiteurs puissants et sélectifs des protéines tyrosines kinases p561ck et p59fyn, conviennent particulièrement à la prophylaxie et au traitement de maladies immunitaires, de maladies hyperproliférantes et d'autres maladies dans lesquelles on pense qu'une activité inappropriée de la p561ck et/ou p59fyn joue un rôle.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)