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1. (WO1998027961) ANTITUSSIVE DRUGS DELIVERED BY PARTIALLY COATED ION EXCHANGE RESINS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/027961 International Application No.: PCT/US1997/021483
Publication Date: 02.07.1998 International Filing Date: 19.11.1997
Chapter 2 Demand Filed: 08.07.1998
IPC:
A61K 9/00 (2006.01) ,A61K 9/50 (2006.01) ,A61K 47/48 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
Applicants: WARNER LAMBERT COMPANY[US/US]; 201 Tabor Road Morris Plains, NJ 07950, US
Inventors: WEN, Betty, P.; CA
RAMSAY, Michael, P.; CA
SCHEURER, Heinrich; CA
DOKUZOVIC, Zdravko; CA
LAM, Vincent; CA
Agent: RYAN, M., Andrea; Warner-Lambert Company 201 Tabor Road Morris Plains, NJ 07950 , US
MANSMANN, Ivo; Warner-Lambert Company Legal Division Gödecke AG, Patents 79090 Freiburg, DE
Priority Data:
60/033,45020.12.1996US
Title (EN) ANTITUSSIVE DRUGS DELIVERED BY PARTIALLY COATED ION EXCHANGE RESINS
(FR) MEDICAMENTS ANTITUSSIFS ADMINISTRES PAR DES RESINES ECHANGEUSES D'IONS
Abstract:
(EN) The present invention relates generally to a mixture of coated and non-coated sulfonic acid cation exchange resins (Amberlite IR69) cross-linked with about 8 % divinyl benzene onto which dextromethorphan has been loaded. About 30 % of the drug/resin complexes are coated with a mixture of ethyl cellulose or ethyl cellulose latexes with plasticizers and water dispersible polymers such as SURELEASE. The coating level is about 50 % w/w drug. Coated and uncoated drug/resin complexes are loaded with drug to about 45 % by weight drug/resin complex. The ratio of coated and uncoated drug/resin complexes is about 55/45. The particle sizes of the coated and uncoated drug/resin complexes is about 20 to about 300 and about 20 to about 250 microns, respectively.
(FR) La présente invention concerne d'une manière générale un mélange de résines échangeuses de cations d'acide sulfonique enrobées et non enrobées (Amberlite IR69) réticulées avec environ 8 % de divinylbenzène dans lesquelles on a chargé du dextrométhorphane. Environ 30 % des complexes médicaments/résines sont enrobés d'un mélange d'éthylcellulose ou de latex d'éthylcellulose présentant des plastifiants et des polymères dispersibles dans l'eau tels que SURELEASE. Le niveau d'enrobage se situe environ à 50 % en poids du médicament. Des complexes de médicaments/résines enrobés et non enrobés sont chargés d'un médicament jusqu'à environ 45 % en poids du complexe médiacament/résine. Le rapport entre les complexes de médicament/résine enrobés et non enrobés est d'environ 55/45. Les grosseurs de particules des complexes de médicament/résine enrobés et non enrobés vont d'environ 20 à environ 300 et d'environ 20 à environ 250 microns, respectivement.
Designated States: AL, AU, BA, BB, BG, BR, CA, CN, CZ, EE, GE, HU, ID, IL, IS, JP, KR, LC, LK, LR, LT, LV, MG, MK, MN, MX, NO, NZ, PL, RO, SG, SI, SK, SL, TR, TT, UA, UZ, VN, YU
African Regional Intellectual Property Organization (ARIPO) (GH, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)