Processing

Please wait...

PATENTSCOPE will be unavailable a few hours for maintenance reason on Tuesday 26.10.2021 at 12:00 PM CEST
Settings

Settings

Goto Application

1. WO1998025911 - 1,5-BENZODIAZEPINE DERIVATIVES

Publication Number WO/1998/025911
Publication Date 18.06.1998
International Application No. PCT/JP1997/004534
International Filing Date 10.12.1997
Chapter 2 Demand Filed 12.05.1998
IPC
C07D 243/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
243Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
06having the nitrogen atoms in positions 1 and 4
10condensed with carbocyclic rings or ring systems
121,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
C07D 401/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 403/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 403/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 405/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 405/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
CPC
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 1/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
06Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
A61P 25/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
16Anti-Parkinson drugs
A61P 25/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
A61P 25/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
22Anxiolytics
A61P 25/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
24Antidepressants
Applicants
  • ZERIA PHARMACEUTICAL CO., LTD. [JP]/[JP] (AllExceptUS)
  • SHINOZAKI, Katsuo [JP]/[JP] (UsOnly)
  • YONETA, Tomoyuki [JP]/[JP] (UsOnly)
  • MURATA Masakazu [JP]/[JP] (UsOnly)
  • MIURA, Naoyoshi [JP]/[JP] (UsOnly)
  • MAEDA, Kiyoto [JP]/[JP] (UsOnly)
Inventors
  • SHINOZAKI, Katsuo
  • YONETA, Tomoyuki
  • MURATA Masakazu
  • MIURA, Naoyoshi
  • MAEDA, Kiyoto
Agents
  • ARUGA, Mitsuyuki
Priority Data
8/34449810.12.1996JP
9/15613230.05.1997JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) 1,5-BENZODIAZEPINE DERIVATIVES
(FR) DERIVES DE 1,5-BENZODIAZEPINE
Abstract
(EN)
1,5-Benzodiazepine derivatives represented by general formula (I), salts thereof, and medicines containing the same as the active ingredient: (wherein R1 represents hydrogen, lower alkyl, lower alkoxy or halogeno; R2 and R3 may be the same or different and each represents hydrogen, alkenyl, alkyl, phenyl, acyl, etc.; and R4 and R5 may be the same or different and each represents hydrogen, alkyl, carboxyl, etc.). The compounds have an excellent gastrin and/or CCK-B receptor antagonism and are useful as remedies for gastric ulcer and gastrointestinal movement disorder.
(FR)
La présente invention concerne des dérivés de 1,5-benzodiazépine représentés par la formule générale (I), des sels de ces derniers et des médicaments contenant lesdits dérivés en tant qu'ingrédient actif. Dans ladite formule (I) R1 représente hydrogène, alkyle inférieur, alcoxy inférieur ou halogéno; R2 et R3 peuvent être identiques ou différents et représentent chacun hydrogène, alcényle, alkyle, phényle, acyle, etc.; et R4 et R5 peuvent être identiques ou différents et représentent chacun hydrogène, alkyle, carboxyle, etc.. Les composés de l'invention présentent un excellent antagonisme par rapport au récepteur de CCK-B et/ou de la gastrine et sont utilisés comme médicaments pour l'ulcère gastrique et les troubles gastro-intestinaux.
Latest bibliographic data on file with the International Bureau