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1. WO1998024808 - INHIBITION OF IgE-MEDIATED ALLERGIES BY A HUMAN IgE-DERIVED OLIGOPEPTIDE

Publication Number WO/1998/024808
Publication Date 11.06.1998
International Application No. PCT/US1997/022348
International Filing Date 05.12.1997
Chapter 2 Demand Filed 29.06.1998
IPC
A61K 38/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 16/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
G01N 33/68 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 16/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
G01N 33/6854
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6854Immunoglobulins
Applicants
  • THE UNITED STATES OF AMERICA represented by THE SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES, THE NATIONAL INSTITUTES OF HEALTH [US]/[US] (AllExceptUS)
  • PADLAN, Eduardo, A. [US]/[US] (UsOnly)
  • BIRGIT, A., Helm [DE]/[GB] (UsOnly)
Inventors
  • PADLAN, Eduardo, A.
  • BIRGIT, A., Helm
Agents
  • EARP, David, J.
Priority Data
60/031,99106.12.1996US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) INHIBITION OF IgE-MEDIATED ALLERGIES BY A HUMAN IgE-DERIVED OLIGOPEPTIDE
(FR) INHIBITION D'ALLERGIES PROVOQUEES PAR L'IMMUNOGLOBULINE E GRACE A UN OLIGOPEPTIDE DERIVE DE L'IMMUNOGLOBULINE E HUMAINE
Abstract
(EN) Peptides are disclosed that are capable of effective recognition of the human IgE Fc$g(e) receptor. The peptides partially comprises a fragment of human IgE. By addition of constraining amino acid residues at or near the polypeptides' N- and C-termini, these peptides may be forced to assume a loop configuration. These constrained peptides are useful as competitors of human IgE for the Fc$g(e) receptor, and may be used to block the development of type I hypersensitivity.
(FR) L'invention concerne des peptides capables de reconnaître effectivement le récepteur Fc$g(e) de l'immunoglobuline E humaine. Les peptides comprennent en partie un fragment d'immunoglobuline E humaine. En ajoutant des résidus d'acides aminés de contrainte aux terminaisons N et C des polypeptides ou près de ces terminaux, on peut forcer ces peptides à présenter une configuration en boucle. Ces peptides contraints s'utilisent comme concurrents de l'immunoglobuline E humaine pour le récepteur Fc$g(e) et peuvent s'utiliser pour bloquer le développement d'une hypersensibilité de type I.
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