Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO1998024782) SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/024782 International Application No.: PCT/US1997/022390
Publication Date: 11.06.1998 International Filing Date: 04.12.1997
Chapter 2 Demand Filed: 18.05.1998
IPC:
C07D 401/04 (2006.01) ,C07D 401/14 (2006.01) ,C07D 409/14 (2006.01) ,C07D 487/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
SPOHR, Ulrike, D. [CA/US]; US (UsOnly)
MALONE, Michael, J. [US/US]; US (UsOnly)
MANTLO, Nathan, B. [US/US]; US (UsOnly)
AMGEN INC. [US/US]; Amgen Center One Amgen Center Drive Thousand Oaks, CA 91360, US (AllExceptUS)
Inventors:
SPOHR, Ulrike, D.; US
MALONE, Michael, J.; US
MANTLO, Nathan, B.; US
Agent:
ODRE, Steven, M. ; Amgen, Inc. Amgen Center 1840 De Havilland Drive Thousand Oaks, CA 91320-1789, US
Priority Data:
60/032,12805.12.1996US
60/050,95013.06.1997US
null21.11.1997US
Title (EN) SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE
(FR) COMPOSES PYRIMIDINES SUBSTITUES ET LEUR UTILISATION
Abstract:
(EN) Selected novel substituted pyrimidine compounds are effective for prophylaxis and treatment of diseases, such as TNF-$g(a), IL-1$g(b), IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving inflammation, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
(FR) La présente invention concerne de nouveaux composés pyrimidines substitués efficaces en prophylaxie et en traitement contre des affections telles que les affections à médiation du TNF-$g(a), de l'IL-1$g(b), de l'IL-6 et/ou de l'IL-8, et contre des états pathologiques tels que la douleur et le diabète. L'invention, qui concerne également de nouveaux composés et certains de leurs analogues, de leurs promédicaments et de leurs sels pharmaceutiquement acceptables, concerne aussi des compositions pharmaceutiques et des procédés convenant à la prophylaxie et au traitement d'affections, d'états pathologiques ou d'états caractérisés par des phénomènes inflammatoires, algiques, diabétiques et similaires. L'invention concerne enfin des procédés de fabrication de tels composés ainsi que des intermédiaires intervenant dans de tels procédés.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)