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1. WO1998024474 - INHIBITION OF INVASIVE REMODELLING

Publication Number WO/1998/024474
Publication Date 11.06.1998
International Application No. PCT/DK1997/000555
International Filing Date 08.12.1997
Chapter 2 Demand Filed 06.07.1998
IPC
A61K 31/40 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
A61K 38/57 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
55Protease inhibitors
57from animals; from humans
A61K 45/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
CPC
A61K 31/40
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
A61K 38/57
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
55Protease inhibitors
57from animals; from humans
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • FONDEN TIL FREMME AF EKSPERIMENTEL CANCERFORSKNING [DK]/[DK] (AllExceptUS)
  • LUND, Leif, Røge [DK]/[DK] (UsOnly)
  • DANØ, Keld [DK]/[DK] (UsOnly)
  • STEPHENS, Ross [AU]/[DK] (UsOnly)
  • BRÜNNER, Nils [DK]/[DK] (UsOnly)
  • SOLBERG, Helene [DK]/[DK] (UsOnly)
  • HOLST-HANSEN, Claus [DK]/[DK] (UsOnly)
  • NIELSEN, John, Rømer [DK]/[DK] (UsOnly)
Inventors
  • LUND, Leif, Røge
  • DANØ, Keld
  • STEPHENS, Ross
  • BRÜNNER, Nils
  • SOLBERG, Helene
  • HOLST-HANSEN, Claus
  • NIELSEN, John, Rømer
Agents
  • PLOUGMANN, VINGTOFT & PARTNERS A/S
Priority Data
1402/9606.12.1996DK
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) INHIBITION OF INVASIVE REMODELLING
(FR) INHIBITION DU REMODELAGE INVASIF
Abstract
(EN) The invention pertains to novel methods for preventing or arresting invasive remodelling in mammals by utilising a combination of $i(in vivo) inhibition of plasmin and $i(in vivo) inhibition of certain other proteolytic enzymes, notably metalloproteases. The method can e.g. be used as a novel alternative to current methods of contraception as well as antifungal and antibacterial treatment. The preferred embodiments relate to treatment and prevention of neoplastic diseases by use of these combinations. Further, the invention relates to novel compositions which comprises a plasmin inhibitor in admixture with an inhibitor of another proteolytic enzyme, preferably an inhibitor of a metalloprotease.
(FR) Cette invention se rapporte à de nouveaux procédés pour prévenir ou stopper le remodelage invasif chez des mammifères, en utilisant une combinaison d'inhibition $i(in vivo) de plasmine et d'inhibition $i(in vivo) de certaines autres enzymes protéolytiques, notamment les métalloprotéases. Ce procédé peut être utilisé par exemple comme une nouvelle alternative aux procédés courants de contraception ainsi que de traitement antifongique et antibactérien. Les modes de réalisation préférés se rapportent au traitement et à la prévention de maladies néoplasiques grâce à l'utilisation de ces combinaisons. Cette invention concerne en outre de nouvelles compositions qui contiennent un inhibiteur de plasmine mélangé à un inhibiteur d'une autre enzyme protéolytique, de préférence un inhibiteur d'une métalloprotéase.
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