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1. WO1998023311 - METHOD AND SYSTEM FOR PREVENTING INTRADIALYTIC SYMPTOMATOLOGY

Publication Number WO/1998/023311
Publication Date 04.06.1998
International Application No. PCT/SE1997/001879
International Filing Date 11.11.1997
Chapter 2 Demand Filed 23.04.1998
IPC
A61M 1/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
14Dialysis systems; Artificial kidneys; Blood oxygenators
16with membranes
A61M 1/34 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration, diafiltration
CPC
A61M 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
14Dialysis systems; Artificial kidneys; Blood oxygenators; ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for haemofiltration, pheris
16with membranes
A61M 1/1609
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
14Dialysis systems; Artificial kidneys; Blood oxygenators; ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for haemofiltration, pheris
16with membranes
1601Control or regulation
1603Regulation parameters
1605Physical characteristics of the dialysate fluid
1609after use
A61M 1/1613
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
14Dialysis systems; Artificial kidneys; Blood oxygenators; ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for haemofiltration, pheris
16with membranes
1601Control or regulation
1613Profiling or modelling
A61M 1/341
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
34Filtering material out of the blood by passing it through a membrane, i.e. haemofiltration, diafiltration
3403Regulation parameters
341by measuring the filtrate rate, volume
A61M 1/3413
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
34Filtering material out of the blood by passing it through a membrane, i.e. haemofiltration, diafiltration
3413Diafiltration
A61M 1/3465
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
34Filtering material out of the blood by passing it through a membrane, i.e. haemofiltration, diafiltration
342Adding solutions to the blood, e.g. substitution solutions
3455Substitution fluids
3465using dialysate as substitution fluid
Applicants
  • GAMBRO AB [SE]/[SE] (AllExceptUS)
  • SHALDON, Stanley [GB]/[FR] (UsOnly)
  • GRANOLLERAS, Céline [FR]/[FR] (UsOnly)
Inventors
  • SHALDON, Stanley
  • GRANOLLERAS, Céline
Agents
  • ASKETORP, Göran
Priority Data
9604370-828.11.1996SE
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD AND SYSTEM FOR PREVENTING INTRADIALYTIC SYMPTOMATOLOGY
(FR) METHODE ET SYSTEME DE PREVENTION DE SYMPTOMATOLOGIE INTRADIALYTIQUE
Abstract
(EN) A method and system for profiling the efficiency of a dialysis treatment, whereby a patient is exposed for dialysis by passing the patient's blood in an extracorporeal circuit through a dialyzer. The effluent fluid from the dialyzer (or hemofilter) is analyzed for the concentration of urea, by a urea monitor, or any other marker molecule. The dialysis treatment is carried out as efficient as possible until a limit value is reached indicative of the fact that the patient is approaching a break-down point, such as disequilibrium syndrome or hypotension. Thence, the efficiency of the dialysis treatment is profiled so that the patient will not reach his break-down point. The efficiency can be decreased according to an exponential curve. Alternatively, the urea monitor controls the efficiency. The limit value is determined by urea monitor measurement, or by predetermined patient data in a characteristic patient break-down curve. One indication is that the total removed urea (TRU) is determined and when the TRU reaches a predetermined value, it is an indication of reaching said limit value.
(FR) Une méthode et un système d'optimisation de l'efficacité d'un traitement de dialyse consiste à soumettre un patient à une dialyse consistant à faire passer le sang du patient dans un circuit extracorporel à travers un dialyseur. Le fluide effluent du dialyseur (ou hémofiltre) est analysé afin de déterminer la concentration d'urée, à l'aide d'un moniteur d'urée, ou de toute autre molécule de marqueur. Le traitement de dialyse est exécuté de manière aussi efficace que possible jusqu'à ce qu'une valeur limite soit atteinte, indiquant le fait que le patient approche un point de rupture, tel que le syndrome de déséquilibre ou l'hypotension. Par conséquent, l'efficacité du traitement de dialyse est profilée de manière que le patient n'obtienne pas son point de rupture. L'efficacité peut être réduite selon une courbe exponentielle. Dans une variante, le moniteur d'urée contrôle l'efficacité. La valeur limite est déterminée par mesure du moniteur d'urée ou par une date prédéterminée du patient dans une courbe de rupture caractéristique du patient. Une indication réside dans le fait que l'urée extraite totale est déterminée et lorsque l'urée extraite totale atteint une valeur prédéterminée, elle indique que la valeur limite est atteinte.
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