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Machine translation
1. (WO1998017806) MINI-E1A GENES AND GENE PRODUCTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/017806    International Application No.:    PCT/US1997/019042
Publication Date: 30.04.1998 International Filing Date: 20.10.1997
Chapter 2 Demand Filed:    18.05.1998    
IPC:
A61K 38/00 (2006.01), A61K 48/00 (2006.01), C07K 14/075 (2006.01)
Applicants: TARGETED GENETICS CORPORATION [US/US]; Suite 100, 1100 Olive Way, Seattle, WA 98101 (US) (For All Designated States Except US).
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US/US]; 201 West 7th Street, Austin, TX 78701 (US) (For All Designated States Except US).
HUNG, Mien-Chie [--/US]; (US) (For US Only).
CHEN, Hua [CN/US]; (US) (For US Only).
YU, Di-Hua [CN/US]; (US) (For US Only).
PAUL, Ralph, Wilfred [CA/US]; (US) (For US Only).
LOOMIS, Aaron, Garth [US/US]; (US) (For US Only).
LAFOE, Daniel, Nathan, Andrew [US/US]; (US) (For US Only)
Inventors: HUNG, Mien-Chie; (US).
CHEN, Hua; (US).
YU, Di-Hua; (US).
PAUL, Ralph, Wilfred; (US).
LOOMIS, Aaron, Garth; (US).
LAFOE, Daniel, Nathan, Andrew; (US)
Agent: WILSON, Mark, B.; Arnold, White & Durkee, P.O. Box 4433, Houston, TX 77210 (US).
GOWSHALL, Jonathan, Vallance; Forrester & Boehmert, Franz-Joseph-Strasse 38, D-80801 München (DE)
Priority Data:
08/730,910 18.10.1996 US
Title (EN) MINI-E1A GENES AND GENE PRODUCTS
(FR) GENES MINI-E1A ET PRODUITS GENIQUES
Abstract: front page image
(EN)The present invention provides methods and compositions for the suppression of oncogenic transformation, tumorigenesis and metastasis. The present invention discloses functional domains of E1A responsible for the suppression of transformation, and provides mini-E1A constructs that can be used for tumor suppression. The invention also discloses methods for the novel use of mini-E1A in combination with chemotherapeutic drugs and/or tyrosine kinase inhibitors.
(FR)La présente invention concerne des procédés et des compositions destinés à la suppression de transformations oncogènes, de l'oncogenèse et de métastases. Des domaines fonctionnels de E1A responsables de la suppression de transformations sont décrits, ainsi que des constructions de mini-E1A pouvant être utilisées dans la suppression de tumeurs. Sont également décrits des procédés destinés à l'utilisation nouvelle de mini-E1A en combinaison avec des médicaments chimiothérapeutiques et/ou des inhibiteurs de tyrosine kinase.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, GH, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)